7637-33-4Relevant articles and documents
Continuous flow enables metallaphotoredox catalysis in a medicinal chemistry setting: Accelerated optimization and library execution of a reductive coupling between benzylic chlorides and aryl bromides
Brill, Zachary G.,Ritts, Casey B.,Mansoor, Umar Faruk,Sciammetta, Nunzio
supporting information, p. 410 - 416 (2020/01/21)
Continuous flow has been used widely in process chemistry and academic settings for various applications. However, initial reaction discovery has generally remained "batch-exclusive" despite the existence of efficient, reproducible flow systems. We hereby disclose a workflow to bridge the gap between early medicinal chemistry efforts and process-scale development, showcased by the discovery and optimization of a metallaphotoredox-catalyzed cross-coupling between benzylic chlorides and aryl bromides, followed by two library syntheses of complex drug-like compounds.
