76398-88-4

Basic information

• Product Name: (S)-3-(4-Acetylamino-phenyl)-2-amino-N-[(2S,3S,4R,5R)-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-propionamide
• Synonyms: (S)-3-(4-Acetylamino-phenyl)-2-amino-N-[(2S,3S,4R,5R)-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-propionamide
• CAS NO: 76398-88-4
• Molecular Weight: 498.542
• Mol File: 76398-88-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-(4-Acetylamino-phenyl)-2-amino-N-[(2S,3S,4R,5R)-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-Acetylamino-phenyl)-2-amino-N-[(2S,3S,4R,5R)-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-propionamide(76398-88-4)
• EPA Substance Registry System: (S)-3-(4-Acetylamino-phenyl)-2-amino-N-[(2S,3S,4R,5R)-5-(6-dimethylamino-purin-9-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl]-propionamide(76398-88-4)

Safety Data

• Hazardous Substances Data: 76398-88-4(Hazardous Substances Data)

Upstream product

• 76494-20-7 6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine 
• 76381-68-5 6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine 
• 33305-77-0 Boc-Phe(p-NO₂)-OH 
• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 76381-69-6 6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine 

Relevant articles and documents

Puromycin Analogues. Effect of Aryl-Substituted Puromycin Analogues on the Ribosomal Peptidyltransferase Reaction

A series of ortho- and para-substituted L-phenylalanylpuromycin analogues were synthesized and evaluated as substrates for the peptidyltransferase reaction of Escherichia coli ribosomes.Kinetic results reveal that substitution of the p-methoxy group of the puromycin molecule alters the peptidyltransferase activity of the molecule with the following decreasing order of substrate efficiencies: p-NH2 > p-NHCOCH3 > p-NO2 = p-NHCO(CH2)2CH3 > p-NHCOCH2Br.However, the inability of the ribosome to tolerate a nitro group at the ortho position of the phenylalanine ring precluded the use of the photosensitive puromycin analogue, 2-nitro-4-azidophenylalanylpuromycin aminonucleoside (7a), as a photoaffinity label for the peptidyltransferase site.