76411-89-7

Basic information

• Product Name: (S)-ethyl 2-phenylbutanoate
• Synonyms: (S)-ethyl 2-phenylbutanoate
• CAS NO: 76411-89-7
• Molecular Weight: 192.258
• Mol File: 76411-89-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (S)-ethyl 2-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ethyl 2-phenylbutanoate(76411-89-7)
• EPA Substance Registry System: (S)-ethyl 2-phenylbutanoate(76411-89-7)

Safety Data

• Hazardous Substances Data: 76411-89-7(Hazardous Substances Data)

Upstream product

• 119-43-7 ethyl 2-phenylbutanoate 
• 90-27-7 2-Phenylbutyric acid 
• 100-58-3 phenylmagnesium bromide 
• 533-68-6 2-bromobutyric acid ethyl ester 
• 60577-21-1 ethyl α-bromo-α-phenylbutyrate 
• 769-68-6 2-phenylbutanenitrile 
• 64-17-5 ethanol 
• 4286-15-1 (S)-2-phenylbutyric acid 

Relevant articles and documents

The quest for single-enantiomer outcomes in free-radical chemistry

A significant challenge facing free-radical chemists is in the area of stereocontrol, specifically the ability to control the direction of reagent attack at a prochiral radical. While significant inroads have been made in the area of diastereoselective ra

Cobalt-bisoxazoline-catalyzed asymmetric kumada cross-coupling of racemic α-bromo esters with aryl grignard reagents

The first cobalt-catalyzed asymmetric Kumada cross-coupling with high enantioselectivity has been developed. The reaction affords a unique strategy for the enantioselective arylation of α-bromo esters catalyzed by a cobalt-bisoxazoline complex. A variety of chiral α-arylalkanoic esters were prepared in excellent enantioselectivity and yield (up to 97% ee and 96% yield). The arylated products were transformed into α-arylcarboxylic acids and primary alcohols without erosion of ee. The new enantioenriched α-arylpropionic esters synthesized herein are potentially useful in the development of nonsteroidal anti-inflammatory drugs. This method was conducted on gram-scale and applied to the synthesis of highly enantioenriched (S)-fenoprofen and (S)-ar-turmerone.

METHOD OF REMOVING ORGANOTIN RESIDUE

The invention provides a method of separating soluble organotin residue from a reduced product of a reduction reaction that uses an organotin hydride as a reducing agent, the method comprising: (i) contacting a reaction medium comprising said reduced product and soluble organotin residue with a substrate which, (a) is substantially insoluble in the reaction medium, (b) binds at least a portion of said soluble organotin residue, and (c) does not substantially bind the reduced product; (ii) separating said substrate from the reaction medium, thereby removing said at least a portion of organotin residue from the reaction medium; andrecovering the reaction medium comprising the reduced product. The invention also provides a method of performing a reduction reaction using an organotin hydride as a reducing agent that incorporates the method of separating soluble organotin residue.