764717-65-9Relevant articles and documents
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor
Osman, Khan T.,Ye, Juntao,Shi, Zhihao,Toker, Christina,Lovato, Diogo,Jumani, Rajiv S.,Zuercher, William,Huston, Christopher D.,Edwards, Aled M.,Lautens, Mark,Santhakumar, Vijayaratnam,Hui, Raymond
, p. 1672 - 1680 (2017)
FIKKs are parasite-specific protein kinases with distinctive sequence motifs and their biological roles have not been completely elucidated. Here, we report the first potent Cryptosporidium FIKK (CpFIKK) inhibitor. We identified 4b as a potent (IC50 = 0.2