764722-71-6

Basic information

• Product Name: (S)-3-[(4'-Ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester
• Synonyms: (S)-3-[(4'-Ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester
• CAS NO: 764722-71-6
• Molecular Weight: 473.528
• Mol File: 764722-71-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-[(4'-Ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-[(4'-Ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester(764722-71-6)
• EPA Substance Registry System: (S)-3-[(4'-Ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester(764722-71-6)

Safety Data

• Hazardous Substances Data: 764722-71-6(Hazardous Substances Data)

Upstream product

• 764722-70-5 4'-Ethyl-biphenyl-4-carboxylic acid methyl-(S)-pyrrolidin-3-yl-amide 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 764722-69-2 4'-Ethyl-biphenyl-4-carboxylic acid ((S)-1-benzyl-pyrrolidin-3-yl)-methyl-amide 
• 5731-13-5 4-(4-ethylphenyl)benzoic acid 
• 169749-99-9 (3S)-(-)-1-benzyl-3-(methylamino)pyrrolidine 

Downstream Products

• 764722-73-8 Methanesulfonic acid (S)-1-{(S)-3-[(4'-ethyl-biphenyl-4-carbonyl)-methyl-amino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl ester 

Relevant articles and documents

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited considerable binding affinity (Ki = 1 nM) and functional activity at MCH-R1, acceptable CYP2D6 inhibition, and good rat brain exposure.