765-77-5Relevant articles and documents
Peptidylarginine deiminase inhibitor and application thereof
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Paragraph 0520; 0522; 0523; 0524, (2019/09/10)
The invention belongs to the technical field of medicine, and particularly relates to a peptidylarginine deiminase PAD4 inhibitor compound shown in a formula (I) or pharmaceutically acceptable salts,stereoisomers and tautomers thereof, as well as pharmaceutical compositions, pharmaceutical preparations and application thereof. X, Y, R1, R2, R3, R4, R5, R7, R8, R9, ring B and m are as defined in the specification. The compound has inhibitory effect on peptidylarginine deiminase PAD4, and can be used for treating various diseases, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, multiple sclerosis, cystic fibrosis, cancer, cutaneous lupus erythematosus, asthma and psoriasis.
4-?(thien-3-yl)methyl!-imidazole analgesics
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, (2008/06/13)
Described herein are 4-?(thien-3-yl)methyl!-imidazoles of the formula: STR1 wherein R is hydrogen or methyl, and X is C1-4 alkyl, bromine or chlorine; or STR2 wherein Y is hydrogen, C1-4 alkyl, bromine or chlorine, and Z is C1-4
Generation and Trapping of (Thiophen-3-yl)halogenocarbenes from 3-Dihalomethylthiophenes or 3-Chloro-3-(thiophen-3-yl)diazirine
Baird, Mark S.,Bruce, Ian
, p. 2872 - 2893 (2007/10/02)
Reaction of 3-dihalogenomethylthiophenes with potassium t-butoxide at 0 deg C generates (thiophen-3-yl)halogenocarbenes, or related carbenoids, which are trapped by simple alkenes to give 1-(thiophen-3-yl)-1-halogenocyclopropanes in moderate to good yield