76510-61-7

Basic information

• Product Name: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE
• Synonyms: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE;5-iodo-2-(Methylthio)pyriMidin-4-ol;5-iodo-2-(methylthio)-4(3H)-Pyrimidinone;2S-Methyl-5-iodo-2-thiouracil;5-iodo-2-methylsulfanyl-1H-pyrimidin-6-one;4(3H)-Pyrimidinone,5-iodo-2-(methylthio)-;5-Iodo-2-(Methylthio)-4(3H)-Pyrimidinone(WX638047)
• CAS NO: 76510-61-7
• Molecular Formula: C₅H₅IN₂OS
• Molecular Weight: 268.08
• Mol File: 76510-61-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE(76510-61-7)
• EPA Substance Registry System: 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE(76510-61-7)

Safety Data

• Hazardous Substances Data: 76510-61-7(Hazardous Substances Data)

Upstream product

• 5751-20-2 2-(methylsulfanyl)pyrimidin-4-ol 
• 5751-20-2 2-Methylthiouracil 
• 6328-58-1 4-Hydroxy-6-methyl-2-methylthiopyrimidine 
• 5751-20-2 2-methylthio-1H-pyrimidin-4-one 

Downstream Products

• 111079-19-7 4-chloro-5-iodo-2-(methylsulfanyl)pyrimidine 
• 66-22-8 uracil 
• 696-07-1 5-iodouracil 
• 1301610-89-8 tert-butyl (1-(4-(2-(methylthio)furo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate 
• 1596364-72-5 (1S,2R,3S,4R)-methyl 2-((tert-butyldiphenylsilyl)oxy)-4-((5-iodo-2-(methylthio)pyrimidin-4-yl)amino)-3-methoxycyclopentanecarboxylate 
• 1596364-73-6 (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate 
• 1596364-76-9 2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol 

Relevant articles and documents

Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR

Aurora A, Aurora B and Kinase Insert Domain-containing Receptor (KDR) play essential roles in sustained cancer growth. In the present study, eighteen pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives were designed and synthesized. Most of the prepa

A New Synthesis of 2-Aminoindoles and 6-Aminopyrrolo[3,2- d ]pyrimidines from π-Deficient 1,2-Dihaloarenes and Geminal Enediamines

An efficient approach for the synthesis of fused 2-aminopyrroles via geminal enediamines and π-deficient 1,2-dihaloarenes is presented. The two-step methodology includes aromatic nucleophilic substitution of the activated halogen of dihaloarene with enediamine C-nucleophilic center followed by Cu-catalyzed intramolecular N-arylation. This approach allows access to a variety of 2-amino-6-nitroindoles and 6-aminopyrrolo[3,2-d]pyrimidines (including N-mono- and N,N-disubstituted) in moderate and good yields under mild conditions.

Microwave-assisted C-5 iodination of substituted pyrimidinones and pyrimidine nucleosides

Direct microwave-assisted iodination of several pyrimidinones and pyrimidine nucleosides with N-iodosuccinimide to give the corresponding 5-iodo derivatives is described. Application of this reaction to polymer-bound pyrimidinones was also investigated.