76513-94-5Relevant articles and documents
Synthesis and analysis of RNA containing 6-trifluoromethylpurine ribonucleoside.
Veliz,Stephens,Beal
, p. 2969 - 2972 (2001)
We report the synthesis of a 5'-DMT-2'-TBDMS-protected phosphoramidite of 6-trifluoromethylpurine ribonucleoside ((TFM)P) and its use in the site-specific incorporation of 6-trifluoromethylpurine into RNA. Properties of (TFM)P-substituted RNA suggest it will be valuable in the study of RNA structure and the binding of RNA-modifying enzymes, particularly the RNA-editing adenosine deaminases. Reaction: see text.