76554-28-4

Basic information

• Product Name: 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-[4-(2-propenyloxy)phenyl]-
• CAS NO: 76554-28-4
• Molecular Formula: C20H20O5
• Molecular Weight: 340.376
• Mol File: 76554-28-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-[4-(2-propenyloxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-[4-(2-propenyloxy)phenyl]-(76554-28-4)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-[4-(2-propenyloxy)phenyl]-(76554-28-4)

Safety Data

• Hazardous Substances Data: 76554-28-4(Hazardous Substances Data)

Upstream product

• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 40663-68-1 4-(2-propenyloxy)benzaldehyde 

Downstream Products

• 1167577-15-2 C₂₀H₁₈O₅ 
• 1612891-70-9 2-(4-(2-bromoethoxy)phenyl)-5,7-dimethoxychromen-4-one 
• 1612891-71-0 2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethoxychromen-4-one 
• 1612891-72-1 5,7-dimethoxy-2-(4-(1-methylpiperidin-4-yloxy)phenyl)chromen-4-one 
• 1612891-73-2 5,7-dimethoxy-2-(4-(2-morpholin-4-ylethoxy)phenyl)chromen-4-one 
• 1612891-74-3 2-(4-(3-dimethylaminopropoxy)phenyl)-5,7-dimethoxychromen-4-one 
• 1612891-75-4 1-(2-(4-(5,7-dimethoxy-4-oxo-4H-chromen-2-yl)phenoxy)ethyl)pyrrolidin-2-one 
• 1612891-76-5 5,7-dimethoxy-2-(4-(2-piperidin-1-ylethoxy)phenyl)chromen-4-one 
• 1612891-77-6 5,7-dimethoxy-2-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)chromen-4-one 
• 1612891-78-7 5,7-dimethoxy-2-(4-(2-pyrrolidin-1-ylethoxy)phenyl)chromen-4-one 
• 1612891-79-8 2-(4-(2-diethylaminoethoxy)phenyl)-5,7-dimethoxychromen-4-one 
• 1612891-81-2 5,7-dimethoxy-2-(4-(piperidin-4-yloxy)phenyl)chromen-4-one 
• 1612891-82-3 2-(4-(2-aminoethoxy)phenyl)-5,7-dimethoxychromen-4-one 
• 1612891-83-4 2-(4-(3-aminopropoxy)phenyl)-5,7-dimethoxychromen-4-one 

Relevant articles and documents

Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

Accumulating evidence suggests that activated pancreatic stellate cells (PSC) play an important role in chronic pancreatitis (CP), and inhibition of the activated PSC is considered as a potential strategy for the treatment and prevention of CP. Herein, we disclose our findings that apigenin and its novel analogues suppress the proliferation and induce apoptosis in PSC, which reduce the PSC-mediated fibrosis in CP. Chemical modifications of apigenin have been directed to build a focused library of O-alkylamino-tethered apigenin derivatives at 4′-O position of the ring C with the attempt to enhance the potency and drug-like properties including aqueous solubility. A number of compounds such as 14, 16, and 24 exhibited potent antiproliferative effects as well as improved aqueous solubility. Intriguingly, apigenin, new analogues 23 and 24 displayed significant efficacy to reduce pancreatic fibrosis even at a low dose of 0.5 mg/kg in our proof-of-concept study using a preclinical in vivo mouse model of CP.