76561-16-5

Basic information

• Product Name: 4-Bromoisatoic anhydride
• Synonyms: 4-Bromo-isatoic anhydride;7-Bromo-1H-benzo[d][1,3]oxazine-2,4-dione;7-Bromo-2H-3,1-benzoxazine-2,4(1H)-dione;4-Bromoisatoic anhydride 97%;7-Bromo-2H-3,1-benzoxazine-2,4(1H)-dione, 7-Bromo-1H-benzo[d][1,3]oxazine-2,4-dione;4-Bromoisatoicanhydride97%;Isatoic anhydride, 4-bromo-;7-bromo-1H-3,1-benzoxazine-2,4-dione
• CAS NO: 76561-16-5
• Molecular Formula: C₈H₄BrNO₃
• Molecular Weight: 242.03
• Mol File: 76561-16-5.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Density: 1.826
• Refractive Index: 1.623
• Storage Temp.: 2-8°C
• PKA: 9.95±0.20(Predicted)
• CAS DataBase Reference: 4-Bromoisatoic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromoisatoic anhydride(76561-16-5)
• EPA Substance Registry System: 4-Bromoisatoic anhydride(76561-16-5)

Safety Data

• Hazardous Substances Data: 76561-16-5(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H4BrNO3/c9-4-1-2-5-6(3-4)10-8(12)13-7(5)11/h1-3H,(H,10,12)

Upstream product

• 65971-74-6 (E)-N-(3-bromophenyl)-2-(hydroxyimino)acetamide 
• 6326-79-0 6-bromoisatin 
• 75-44-5 phosgene 
• 20776-50-5 2-amino-4-bromobenzoic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 541-41-3 chloroformic acid ethyl ester 
• 1183031-46-0 4-bromo-2-((tert-butoxycarbonyl)amino)benzoic acid 

Downstream Products

• 76561-17-6 2'-amino-4'-bromo-(2-methylsulphinyl) acetophenone 
• 864866-77-3 N-methyl-2-amino-4-bromobenzamide 
• 1312453-66-9 4-bromo-2-(3-methoxypropanamido)-N-methylbenzamide 
• 1332526-71-2 (4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(piperidin-4-yl)methanone 
• 1332526-60-9 3-methylsulfanyl-1-phenyl-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indazole 
• 1332526-61-0 3-methylsulfanyl-1-phenyl-6-(pyridin-4-yl)-1H-indazole 
• 1345403-95-3 C₁₃H₉BrN₂S 
• 1332527-03-3 6-bromo-3-methoxy-1-phenyl-1H-indazole 
• 1332527-04-4 6-Bromo-3-methylsulfanyl-1-phenyl-1H-indazole 
• 1332526-99-4 6-Bromo-1-phenyl-1,2-dihydro-indazol-3-one 
• 1204536-73-1 2-Amino-7-(4-aminophenyl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Amide 
• 1464158-03-9 tert-butyl 4-(2-amino-4-bromobenzoyl)piperazine-1-carboxylate 
• 1464155-12-1 (2-amino-4-bromophenyl)(4-(dimethylamino)piperidin-1-yl)methanone 
• 1464155-15-4 N-(5-bromo-2-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)acetamide 

Relevant articles and documents

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Carbene-Catalyzed Enantioselective Decarboxylative Annulations to Access Dihydrobenzoxazinones and Quinolones

A direct decarboxylative strategy for the generation of aza-o-quinone methides (aza-o-QMs) by N-heterocyclic carbene (NHC) catalysis has been discovered and explored. This process requires no stoichiometric additives in contrast with current approaches. Aza-o-QMs react with trifluoromethyl ketones through a formal [4+2] manifold to access highly enantioenriched dihydrobenzoxazin-4-one products, which can be converted to dihydroquinolones through an interesting stereoretentive aza-Petasis–Ferrier rearrangement sequence. Complementary dispersion-corrected density functional theory (DFT) studies provided an accurate prediction of the reaction enantioselectivity and lend further insight to the origins of stereocontrol. Additionally, a computed potential energy surface around the major transition structure suggests a concerted asynchronous mechanism for the formal annulation.

BENZAMIDE DERIVATIVE

The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R1, Z and Q are as described in the description.