76569-43-2

Basic information

• Product Name: 2,4-DIMETHOXYBENZOYLACETONITRILE
• Synonyms: 2,4-DIMETHOXYBENZOYLACETONITRILE;2,4-Dimethoxy-b-oxo-benzenepropanenitrile
• CAS NO: 76569-43-2
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.21
• Mol File: 76569-43-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 401.9°C at 760 mmHg
• Flash Point: 175.8°C
• Appearance: /
• Density: 1.147g/cm³
• Vapor Pressure: 1.14E-06mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DIMETHOXYBENZOYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXYBENZOYLACETONITRILE(76569-43-2)
• EPA Substance Registry System: 2,4-DIMETHOXYBENZOYLACETONITRILE(76569-43-2)

Safety Data

• Hazardous Substances Data: 76569-43-2(Hazardous Substances Data)

Usage

General Description

2,4-Dimethoxybenzoyl acetonitrile is a chemical compound with the molecular formula C11H11NO3. It is commonly used as a starting material in the synthesis of various pharmaceuticals and agrochemicals. 2,4-DIMETHOXYBENZOYLACETONITRILE is known for its ability to react with nucleophiles to produce a wide range of substituted products. It has also been studied for its potential use in organic synthesis and medicinal chemistry due to its unique chemical properties. Overall, 2,4-Dimethoxybenzoyl acetonitrile is a versatile and important chemical compound with potential applications in various fields of science and industry.

InChI:InChI=1/C11H11NO3/c1-14-8-3-4-9(10(13)5-6-12)11(7-8)15-2/h3-4,7H,5H2,1-2H3

Upstream product

• 2150-41-6 methyl 2, 4-dimethoxybenzoate 
• 75-05-8 acetonitrile 
• 109-77-3 malononitrile 
• 151-10-0 1,3-Dimethoxybenzene 
• 151-50-8 potassium cyanide 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 829-20-9 2',4'-dimethoxyacetophenone 

Downstream Products

• 179327-21-0 2-amino-3-(2,4-dimethoxybenzoyl)-4,5-dimethylthiophene 
• 103861-03-6 2-(2,4-dimethoxyphenyl)thiazoline 
• 179327-36-7 6-chloromethyl-4-(2,4-dimethoxy-phenyl)-2,3-dimethyl-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester 
• 1476782-08-7 5-(2,4-dimethoxyphenyl)furan-2,3,4-tricarbonitrile 
• 501326-00-7 3-(2,4-dimethoxyphenyl)isoxazol-5-amine 

Relevant articles and documents

Synthesis of 4-Quinolones: N,O-Bis(trimethylsilyl)acetamide-Mediated Cyclization with Cleavage of Aromatic C-O Bond

The synthesis of 1,4-dihydro-4-oxoquinoline derivatives (4-quinolones) based on a BSA [N,O-bis(trimethylsilyl)acetamide]-mediated cyclization of substituted 1-(2-methoxyphenyl)-3-(alkyl/arylamino)prop-2-en-1-ones is described. The reaction belongs to a rare set of cyclizations in which a methoxy group serves as the leaving group. Reaction takes place by the action of silylating agent under mild conditions and provides high yields of pure products following simple aqueous work-up. The versatility of the approach is exemplified by a wide range of 1-alkyl/aryl 3-carboxylates and 3-nitriles that have been prepared. A crucial advantage of this approach is the facile availability of starting methoxy compounds enabling new synthetic possibilities as well as improved cost efficiency. A new approach to the synthesis of 1,4-dihydro-4-oxoquinoline (4-quinolone) derivatives using a BSA-mediated reaction was developed; this entails an example of rare cyclizations in which an OMe group serves as a leaving group. This transformation has great synthetic potential due to the phenolic framework of starting materials and the mildness of the reagent.

Thienopyridine or thienopyrimidine derivatives and their use

This invention provides an anti-inflammatory agent, particularly an agent for treating arthritis, and a bone resorption inhibiting agent, containing a thienopyridine or thienopyrimidine derivative or a salt thereof. This invention also provides a novel th