76574-45-3

Basic information

• Product Name: 5-Pyrimidinecarbonitrile, 4-amino-2-ethyl- (9CI)
• Synonyms: 5-Pyrimidinecarbonitrile, 4-amino-2-ethyl- (9CI)
• CAS NO: 76574-45-3
• Molecular Formula: C₇H₈N₄
• Molecular Weight: 148.16522
• Product Categories: PYRIMIDINE
• Mol File: 76574-45-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Pyrimidinecarbonitrile, 4-amino-2-ethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarbonitrile, 4-amino-2-ethyl- (9CI)(76574-45-3)
• EPA Substance Registry System: 5-Pyrimidinecarbonitrile, 4-amino-2-ethyl- (9CI)(76574-45-3)

Safety Data

• Hazardous Substances Data: 76574-45-3(Hazardous Substances Data)

Upstream product

• 631-58-3 thiopropanamide 
• 672-25-3 aminomethylene-malononitrile 
• 39800-84-5 propamidine 
• 123-06-8 Ethoxymethylenemalononitrile 
• 1070-17-3 ethyl acetimidate 
• 3599-89-1 propionamidine hydrochloride 

Downstream Products

• 76574-51-1 4-amino-2-ethylpyrimidine-5-carbaldehyde 
• 1886-36-8 5-aminomethyl-2-ethyl-pyrimidin-4-ylamine 
• 76587-29-6 2-Ethyl-6-o-tolyl-pyrido[2,3-d]pyrimidin-7-ylamine 
• 76574-95-3 6-(2-Chloro-phenyl)-2-ethyl-pyrido[2,3-d]pyrimidin-7-ylamine 
• 76574-97-5 2-Cyclopropyl-6-o-tolyl-pyrido[2,3-d]pyrimidin-7-ylamine 
• 76574-96-4 6-(2-Bromo-phenyl)-2-cyclopropyl-pyrido[2,3-d]pyrimidin-7-ylamine 
• 76574-98-6 2-Cyclopropyl-6-(2,6-dichloro-phenyl)-pyrido[2,3-d]pyrimidin-7-ylamine 
• 6309-04-2 4-Amino-2-aethyl-5-<<4-methyl-5-(2-hydroxy-aethyl)-thiazolio>-methyl>-pyrimidin Bromid-hydrobromid 

Relevant articles and documents

PHARMACEUTICAL CONSISTING OF CYCLIC AMINOMETHYL PYRIMIDINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a cyclic aminomethyl pyrimidine derivative and a pharmaceutically acceptable salt thereof exhibiting effects on dopamine D4 receptor with high selectivity and useful as a treatment agent of central nervous system diseases such as attention deficit hyperkinesis disorder. SOLUTION: There is provide a compound represented by the formula (1) and a pharmaceutically acceptable salt thereof. (1), where n and m are each independently 1 or 2, Ra is a C1-6 alkyl group, a C3-6 cycloalkyl group or an amino group, Rb is H, a C1-6 alkyl group or an alkyl group-substituted/unsubstituted amino group, Rb is H when Ra is the amino group, Rc1 and Rc2 are each independently H or a C1-6 alkyl group, Rd1 and Rd2 are each independently H, F or a C1-6 alkyl group, a ring Q is substituted/unsubstituted 5- to 10-membered nitrogen-containing heteroaryl group and bond containing break lines is a single bond or a double bond. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Antihypertensive Activity of 6-Arylpyridopyrimidin-7-amine Derivatives

A series of 51 6-arylpyridopyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat.A number of these compounds, notably 6-(2,6-dichlorophenyl)-2-methylpyridopyrimidin-7-amine (36), lowered blood pressure in these rats in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg.Normalized blood pressure levels could then be maintained by single daily oral doses.The effect of structural variation in the 6-aryl group and in the 2 and 4 positions of the pyridopyrimidine ring on activity is reported and discussed.