76576-76-6

Basic information

• Product Name: 3-chloro-2-methyl-4H-chromen-4-one
• Synonyms: 3-chloro-2-methyl-4H-chromen-4-one
• CAS NO: 76576-76-6
• Molecular Weight: 194.617
• Mol File: 76576-76-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-chloro-2-methyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2-methyl-4H-chromen-4-one(76576-76-6)
• EPA Substance Registry System: 3-chloro-2-methyl-4H-chromen-4-one(76576-76-6)

Safety Data

• Hazardous Substances Data: 76576-76-6(Hazardous Substances Data)

Upstream product

• 5751-48-4 2-methylchromone 

Relevant articles and documents

A Copper Halide Promoted Regioselective Halogenation of Coumarins Using N-Halosuccinimide as Halide Source

A safe, convenient, and regioselective synthesis of 3-halo coumarins using a metal halide (CuX 2 alone or with ZnX 2) promoted halogenation with N -halosuccinimide (NXS) as halide source is reported. The synthesis involved the steady in situ generation of highly reactive positive halogen (X +) by the coordination of copper or zinc with the N -halosuccinimide and subsequent electrophilic aromatic substitution of the electron-deficient coumarins. This procedure works well also for the halogenation of less electron-rich naphthoquinones, flavones, and methoxypsoralen in moderate to quantitative yields. This protocol features simple experimental conditions using readily available inexpensive reagents and provides a convenient approach to the chlorination or bromination of some useful heteroaromatic compounds.

EFFICIENT AND IMPROVED PROCEDURE FOR THE SYNTHESIS OF 3-CHLORO DERIVATIVES OF FLAVONES, CHROMONES AND THEIR SULFUR ANALOGUES

Mild and efficient chlorination of flavones, chromones and their sulfur analogues is realized using Montorillonite-K-10 catalyst and sulfuryl chloride.