765962-75-2Relevant articles and documents
Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles
Hartung, Ingo V.,Pühler, Florian,Neuhaus, Roland,Scholz, Arne,Siemeister, Gerhard,Geisler, Jens,Hillig, Roman C.,Von Ahsen, Oliver,Hitchcock, Marion
, p. 2004 - 2013 (2015/12/23)
Having recently identified a so-far unexplored area adjacent to the known binding site of allosteric mitogen-activated protein kinase kinase (MEK) inhibitors, we now report an extension of these studies by combining our new side chains with different MEK
SUBSTITUTED BENZOSULPHONAMIDES
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Page/Page column 44-45, (2011/05/06)
The present invention relates to substituted benzosulphonamide compounds of general formula (I) : in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations compr
SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY
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Page/Page column 77, (2009/01/20)
This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper- proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.