766-52-9

Basic information

• Product Name: 1-Ethyl-2-methylpiperidine
• Synonyms: 1-Ethyl-2-methylpiperidine;1-Ethyl-2-pipecoline
• CAS NO: 766-52-9
• Molecular Formula: C8H17N
• Molecular Weight: 127.23
• Mol File: 766-52-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• PKA: pK1:10.66(+1) (25°C)
• CAS DataBase Reference: 1-Ethyl-2-methylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Ethyl-2-methylpiperidine(766-52-9)
• EPA Substance Registry System: 1-Ethyl-2-methylpiperidine(766-52-9)

Safety Data

• Hazardous Substances Data: 766-52-9(Hazardous Substances Data)

Usage

Chemical classification

Piperidine derivative

Ethyl group

A two-carbon group attached to the piperidine ring

Methyl group

A one-carbon group attached to the piperidine ring

Usage

Synthesis of various pharmaceuticals and organic compounds

Potential local anesthetic

Ability to numb or reduce pain sensation

Precursor for bioactive compounds

Acts as a starting material for the synthesis of other biologically active substances

Research status

Ongoing investigation of its properties and potential applications

Field of interest

Medicinal chemistry and pharmaceutical development

Upstream product

• 109-06-8 α-picoline 
• 64-17-5 ethanol 
• 412320-65-1 1-ethyl-6-methyl-1,2,3,4-tetrahydro-pyridine 
• 74-96-4 ethyl bromide 
• 109-05-7 2-Methylpiperidin 
• 75-03-6 ethyl iodide 
• 10226-29-6 6-Bromo-2-hexanone 
• 3197-42-0 (S)-2-methylpiperidine 

Relevant articles and documents

Guest/host relationships in the synthesis of the novel cage-based zeolites SSZ-35, SSZ-36, and SSZ-39

Here, we report the synthesis and structure of three high-silica molecular sieves, SSZ-35, SSZ-36, and SSZ-39, that are prepared from a library of 37 different cyclic and polycyclic quaternized amine molecules that are used as structure-directing agents (SDAs). The size and shape of the quaternized amine molecules are purposely designed in order to obtain novel zeolite structures, and the synthesis of these molecules is presented. The selectivity for the three molecular sieve phases is found to depend on both the SDA and the degree of heteroatom lattice substitution of Al3+ or B3+ in the silicate framework. Molecular modeling is utilized to probe the effects of the nonbonded SDA/zeolite-framework interaction energy on the selectivity for the observed molecular sieve phase. The Rietveld refinement of the powder X-ray data confirms the structure of the SSZ-39 zeolite to be isomorphous with the aluminophosphate molecular sieve, SAPO-18 (AEI). The structure of SSZ-36 is found to possess a range of fault probabilities between the two-dimensional channel system, end-member polymorphs, ITQ-3 and RUB-13 (International Zeolite Association Codes ITE and RTH, respectively). The SSZ-35 structure is reported to contain a one-dimensional pore system possessing stacked cages circumscribed by alternating rings of 10 and 18 tetrahedral atoms (10- and 18-membered rings).

Piperidylidene derivatives of carboxy-5H-dibenzo[a,d]cycloheptene

The new 1-alkyl-4-(1, 2, or 3-carboxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine compounds are prepared from the corresponding 1, 2 or 3-carboxy-5H-dibenzo[a,d]cyclohepten-5-one by reaction with a Grignard reagent prepared from a 1-alkyl-4-halo piperidine to form an intermediate carbinol, or a 1, 2 or 3-carboxy-5-(1-alkyl-4-piperidyl)-5H-dibenzo[a,d]cyclohepten-5-ol which is then dehydrated to produce the desired 1-alkyl-4-(1, 2 or 3-carboxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine, or alternatively by hydrolysis of a 1-alkyl-4-(1, 2 or 3-cyano-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine compound to form the corresponding 1-alkyl-4-(1, 2 or 3-carboxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine compound.