766-99-4

Basic information

• Product Name: Benzene, 1-ethynyl-4-iodo-
• Synonyms: Benzene, 1-ethynyl-4-iodo-;1-Ethynyl-4-iodobenzene
• CAS NO: 766-99-4
• Molecular Formula: C₈H₅I
• Molecular Weight: 228.02977
• Mol File: 766-99-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 68-69 °C
• Boiling Point: 221.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.79±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Benzene, 1-ethynyl-4-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-ethynyl-4-iodo-(766-99-4)
• EPA Substance Registry System: Benzene, 1-ethynyl-4-iodo-(766-99-4)

Safety Data

• Hazardous Substances Data: 766-99-4(Hazardous Substances Data)

Usage

Uses

1-Ethynyl-4-iodobenzene is used to synthesize quinoline derivatives.

Upstream product

• 14235-81-5 4-Ethynylaniline 
• 134856-58-9 1-iodo-4-(trimethylsilylethynyl)benzene 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 120517-37-5 4-(3-hydroxy-3-methyl-1-butynyl)-1-iodobenzene 
• 624-38-4 para-diiodobenzene 
• 134856-57-8 1-[4-[2-(trimethylsilyl)ethynyl]phenyl]-3,3-diethyltriazene 
• 630104-26-6 3,3-diethyl-1-(4-iodophenyl)triaz-1-ene 
• 116815-00-0 1-(4-iodophenyl)-1-propyn-3-ol 
• 13329-40-3 4-Iodoacetophenone 
• 55404-82-5 3-Chlor-3-(4-iodphenyl)-acrolein 
• 52914-23-5 4-iodophenethyl alcohol 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1899-09-8 1-(2-bromoethynyl)-4-iodobenzene 
• 934-96-3 4-iodo-1-iodoethynylbenzene 
• 151417-38-8 1,3,5-tris(4-iodophenyl)benzene 
• 862280-69-1 trans-Pt(PEt₃)2(CC-p-C₆H₄-I)(CC-p-C₆H₄-CN) 
• 862280-68-0 trans-Pt(PEt₃)2(CC-p-C₆H₄-I)(CC-p-C₆H₄-NO₂) 

Relevant articles and documents

Photocatalyzed E→Z Contra-thermodynamic Isomerization of Vinyl Boronates with Binaphthol

The photocatalytic contra-thermodynamic E→Z isomerization of vinyl boronates by using a binaphthol catalyst is disclosed. The reaction, based on the transient formation of a suitable chromophore with a BINOL derivative as the catalyst, allowed geometrical isomerization in good-to-excellent Z/E ratio and excellent-to-quantitative yields. The mechanism of this E→Z contra-thermodynamic isomerization was studied, and the formation of a transient chromophore species is suggested.

1,2-Carbopentafluorophenylation of Alkynes: The Metallomimetic Pull-Push Reactivity of Tris(pentafluorophenyl)borane

We report the novel single-step 1,2-dicarbofunctionalization of an arylacetylene with an allylsilane and tris(pentafluorophenyl)borane [B(C6F5)3] involving C?C bond formation with C?H bond scission at the β-position to the silicon atom of an allylsilane and B→C migration of a C6F5 group. The 1,2-carbopentafluorophenylation occurs smoothly without the requirement for a catalyst or heating. Mechanistic studies suggest that the metallomimetic “pull-push” reactivity of B(C6F5)3 imparts consecutive electrophilic and nucleophilic characteristics to the benzylic carbon of the arylacetylene. Subsequent photochemical 6π-electrocyclization affords tetrafluoronaphthalenes, which are important in the pharmaceutical and materials sciences. Owing to the unique reactivity of B(C6F5)3, the 1,2-carbopentafluorophenylation using 2-substituted furan proceeded with ring opening, and the reaction using silyl enolates formed a C?C bond with C?O bond scission at the silyloxy-substituted carbon.

How Large Can We Build a Cyclic Assembly? Impact of Ring Size on Chelate Cooperativity in Noncovalent Macrocyclizations

Self-assembled systems rely on intramolecular cooperative effects to control their growth and regulate their shape, thus yielding discrete, well-defined structures. However, as the size of the system increases, cooperative effects tend to dissipate. We analyze here this situation by studying a set of oligomers of different lengths capped with guanosine and cytidine nucleosides, which associate in cyclic tetramers by complementary Watson–Crick H-bonding interactions. As the monomer length increases, and thus the number of C(sp)–C(sp2) σ-bonds in the π-conjugated skeleton, the macrocycle stability decreases due to a notable reduction in effective molarity (EM), which has a clear entropic origin. We determined the relationship between EM or ΔS and the number of σ-bonds, which allowed us to predict the maximum monomer lengths at which cyclic species would still assemble quantitatively, or whether the cyclic species would not able to compete at all with linear oligomers over the whole concentration range.