76609-17-1

Basic information

• Product Name: 5-bromo-2-(4-fluorophenyl)-1H-indole
• Synonyms: 5-bromo-2-(4-fluorophenyl)-1H-indole
• CAS NO: 76609-17-1
• Molecular Weight: 290.135
• Mol File: 76609-17-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-(4-fluorophenyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-(4-fluorophenyl)-1H-indole(76609-17-1)
• EPA Substance Registry System: 5-bromo-2-(4-fluorophenyl)-1H-indole(76609-17-1)

Safety Data

• Hazardous Substances Data: 76609-17-1(Hazardous Substances Data)

Upstream product

• 882855-95-0 2-(2-amino-5-bromophenyl)acetonitrile 
• 1765-93-1 4-fluoroboronic acid 
• 1196131-73-3 1-(4-bromophenyl)-2-(1-(4-fluorophenyl)ethylidene)hydrazine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 26031-63-0 1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 1196131-68-6 5-bromo-2-(4-fluorophenyl)-1-propyl-1H-indole 

Relevant articles and documents

Palladium-catalyzed tandem addition/cyclization in aqueous medium: Synthesis of 2-arylindoles

An efficient protocol to construct 2-arylindoles was developed through palladium-catalyzed tandem addition/cyclization of potassium aryltrifluoroborates with aliphatic nitriles in aqueous medium. The use of water as the reaction medium makes the synthesis process environmentally benign. A plausible mechanism for the formation of 2-arylindoles involving sequential nucleophilic addition followed by an intramolecular cyclization is proposed. Moreover, the utility of this catalytic tandem transformation was also demonstrated in an efficient gram-scale synthesis. This method provides an alternative synthetic tool for accessing a more diverse array of 2-arylindoles.

Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles

(Chemical Equation Presented) A series of 47 novel N1-alkylated- 2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogues 108-110 have no inhibitory activity.