7661-10-1

Basic information

• Product Name: 3-BROMO-N-(4-BROMOPHENYL)PROPANAMIDE
• Synonyms: BUTTPARK 154\12-96;3-BROMO-N-(4-BROMOPHENYL)PROPANAMIDE;N1-(4-BROMOPHENYL)-3-BROMOPROPANAMIDE;3-Bromo-N-(4-bromophenyl)propionamide, 4-Bromo-N-(3-bromopropanoyl)aniline
• CAS NO: 7661-10-1
• Molecular Formula: C₉H₉Br₂NO
• Molecular Weight: 306.98
• Mol File: 7661-10-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 418.2°Cat760mmHg
• Flash Point: 206.7°C
• Appearance: /
• Density: 1.823g/cm³
• Vapor Pressure: 3.34E-07mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 3-BROMO-N-(4-BROMOPHENYL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-N-(4-BROMOPHENYL)PROPANAMIDE(7661-10-1)
• EPA Substance Registry System: 3-BROMO-N-(4-BROMOPHENYL)PROPANAMIDE(7661-10-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 7661-10-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H9Br2NO/c10-6-5-9(13)12-8-3-1-7(11)2-4-8/h1-4H,5-6H2,(H,12,13)

Upstream product

• 15486-96-1 3-Bromopropionyl chloride 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 7661-25-8 N-(4-bromophenyl)azetidin-2-one 
• 461400-41-9 N-(4-bromophenyl)-3-morpholinopropanamide 
• 1365999-74-1 3-morpholino-N-(4-(pyridin-3-yl)phenyl)propanamide 
• 76228-06-3 6-bromo-2,3-dihydro-4(1H)-quinolinone 

Relevant articles and documents

NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333

A series of ligands based on SEN12333, containing either contracted or elongated alkyl chains, were synthesized and evaluated in molecular docking studies against a homology model of the α7 nicotinic acetylcholine receptor (nAChR) subtype. The predicted binding of all ligands was highly similar, with the exception of the analog containing a 5 methylene unit spacer. However, in vitro competition binding assays revealed that the ligands possessed dissimilar binding affinities, with a Ki range of more than an order of magnitude (Ki = 0.50 to >10 μM), and only SEN12333 itself exhibited functional activity at the α7 nAChR.