7661-15-6Relevant articles and documents
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Heine et al.
, p. 5420 (1955)
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Antineoplastic application of nitrogen oxides as novel histone deacetylase inhibitor
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Paragraph 0040; 0041; 0043; 0045, (2017/10/13)
The invention discloses antineoplastic application of nitrogen oxides as a novel histone deacetylase inhibitor. The nitrogen oxides have a general structural formula as shown in a formula (I) and show potential inhibitory effect on HDAC. Thus, more nitrogen and oxygen can be provided for a ZBG part, observation can be carried out on a plurality of lengths of linker, and structural modification can be implemented on the basis of prior art so as to find out inhibitors with good selectivity on HDAC subtypes and action of the inhibitors on other targets. The nitrogen oxides provided by the invention has the advantages of cheap synthesis raw materials, simple process, high purity, low cost, etc. and are expected to be developed into novel HDAC inhibitor-series antitumor drugs with good selectivity on HDAC subtypes, high efficiency and low toxicity.
1-[(N-(un)substituted)amidoalkyl]spiroindolinonaphthoxazines, their preparation, compositions and (co)polymer matrices containing them
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, (2008/06/13)
The object of the present invention is novel spiroindolinonaphthoxazine compounds as well as the compositions and (co)polymer matrices containing them. Said compounds have interesting photochromic properties. Another object of the present invention is a method of preparing said novel compounds.
