7661-18-9

Basic information

• Product Name: Butanamide, 4-bromo-N-(4-chlorophenyl)-
• CAS NO: 7661-18-9
• Molecular Formula: C10H11BrClNO
• Molecular Weight: 276.56
• Mol File: 7661-18-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanamide, 4-bromo-N-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 4-bromo-N-(4-chlorophenyl)-(7661-18-9)
• EPA Substance Registry System: Butanamide, 4-bromo-N-(4-chlorophenyl)-(7661-18-9)

Safety Data

• Hazardous Substances Data: 7661-18-9(Hazardous Substances Data)

Upstream product

• 927-58-2 4-bromobutyroyl chloride 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 7661-33-8 1-(4-chlorophenyl)pyrrolidin-2-one 

Relevant articles and documents

Lead discovery and optimization of T-type calcium channel blockers

A series of compounds were designed as T-type calcium channel blocker containing 6 or 5 pharmacophore features from structure-based virtual screening. To optimize the suggested structure, over 130 derivatives were synthesized and their inhibitory activities on T-type calcium channel were assayed using in vitro screening system with α1G and α1H clones. For the compounds with higher activities in FDSS assay system, the efficacy was measured by patch-clamp method. Among the library with 5 features, alkaneamide derivatives (7b, 9j, 11b, 11g, 11h) with 4-arylsubstituted piperazine showed better IC50 values than Mibefradil.