76684-89-4 Usage
Description
E-64C is an active metabolite of the protease inhibitor E-64d, which selectively inhibits cysteine proteases such as cathepsin B, cathepsin H, and papain, without affecting serine proteases like trypsin, chymotrypsin, or elastase. It exhibits antiviral properties by reducing the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease and limiting infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein.
Used in Pharmaceutical Industry:
E-64C is used as a cysteine protease inhibitor for detecting autophagy in plants, which can help in understanding the cellular processes and developing potential therapeutic agents targeting autophagy-related diseases.
Used in Virology Research:
E-64C is used as an antiviral agent to study its effects on reducing the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease, as well as its ability to limit infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein. This can aid in the development of novel antiviral strategies and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 76684-89-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,6,8 and 4 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 76684-89:
(7*7)+(6*6)+(5*6)+(4*8)+(3*4)+(2*8)+(1*9)=184
184 % 10 = 4
So 76684-89-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1
76684-89-4Relevant articles and documents
Design, synthesis, and screen of cathepsin K inhibitors
Yu, Ying-Ying,Sun, Wei,Dong, Lei,Liu, Hai-Dong,Jiang, Dan,Xiao, Jun-Hai,Yang, Xiao-Hong,Li, Song
, p. 715 - 718 (2013/07/26)
We synthesized a series of epoxysuccinic acid derivatives and evaluated their in vitro cathepsin K inhibitory activity The screening results show that the potency of compounds 9e, 9d, 9p, 9j and 9k (IC50 ≤ 0.005 μmol/L) were equal to or greater than that of the lead compound 9a. Less hydrophobic compounds showed weaker potency, which can be explained by the hydrophobic nature of the cathepsin K binding pockets.
Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors
Meara, Joseph P.,Rich, Daniel H.
, p. 3357 - 3366 (2007/10/03)
Analogs of the epoxysuccinyl peptide cysteine proteinase inhibitor, EP- 475 (2a), in which the free carboxylate has been replaced by hydroxamic acid, amide, methyl ketone, hydroxyl, and ethyl ester functionalities, have been synthesized. Individual rate c
