767321-63-1

Basic information

• Product Name: (2S)-1-(benzyloxycarbonyl)-5-phenylselenyl-2-propylpiperidin-4-one
• Synonyms: (2S)-1-(benzyloxycarbonyl)-5-phenylselenyl-2-propylpiperidin-4-one
• CAS NO: 767321-63-1
• Molecular Weight: 430.405
• Mol File: 767321-63-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-1-(benzyloxycarbonyl)-5-phenylselenyl-2-propylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-(benzyloxycarbonyl)-5-phenylselenyl-2-propylpiperidin-4-one(767321-63-1)
• EPA Substance Registry System: (2S)-1-(benzyloxycarbonyl)-5-phenylselenyl-2-propylpiperidin-4-one(767321-63-1)

Safety Data

• Hazardous Substances Data: 767321-63-1(Hazardous Substances Data)

Upstream product

• 213197-97-8 1,4-dihydro-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-pyridin-4(1H)-one 
• 121675-89-6 (2S)-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-2-n-propyl-5,6-didehydro-piperidin-4-one 
• 27248-04-0 4-((trimethylsilyl)oxy)pyridine 
• 501-53-1 benzyl chloroformate 
• 767321-62-0 (2S)-5-(phenylselenyl)-2-propyl-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)piperidin-4-one 

Downstream Products

• 767321-65-3 (2S,6R)-1-(benzyloxycarbonyl)-6-(3-chloropropyl)-2-propylpiperidin-4-one 
• 142764-69-0 N-(benzyloxycarbonyl)-(6S)-2,3-didehydro-6-n-propylpiperidin-4-one 

Relevant articles and documents

Stereoselective synthesis of enantiomerically pure piperidine derivatives by N-galactosylation of pyridones

Stereoselective desymmetrization of 4-pyridone has been achieved through selective N-galactosylation, activation of the N-(galactosyl)pyridone by O-silylation and immediate addition of Grignard compounds. Chiral piperidine derivatives, e.g. (S)-(+)-coniine and (5S,9S)-(+)-indolozidine 167B, were synthesised in enantiomerically pure form using these highly regio- and stereoselective reactions. After N-galactosylation of 2-pyridone and O-silylation of the N-galactosyl-2-pyridone, addition of a Grignard compound proceeded with high 1,4-regioselectivity and complete diastereoselectivity, to furnish 4-substituted 5,6-dehydro-2-piperidones. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.