767341-27-5

Basic information

• Product Name: Acetic acid 3-((1R,2S)-2,3-dihydroxy-1-phenylsulfanylmethyl-propylcarbamoyl)-2-methyl-phenyl ester
• Synonyms: Acetic acid 3-((1R,2S)-2,3-dihydroxy-1-phenylsulfanylmethyl-propylcarbamoyl)-2-methyl-phenyl ester
• CAS NO: 767341-27-5
• Molecular Weight: 389.472
• Mol File: 767341-27-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid 3-((1R,2S)-2,3-dihydroxy-1-phenylsulfanylmethyl-propylcarbamoyl)-2-methyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 3-((1R,2S)-2,3-dihydroxy-1-phenylsulfanylmethyl-propylcarbamoyl)-2-methyl-phenyl ester(767341-27-5)
• EPA Substance Registry System: Acetic acid 3-((1R,2S)-2,3-dihydroxy-1-phenylsulfanylmethyl-propylcarbamoyl)-2-methyl-phenyl ester(767341-27-5)

Safety Data

• Hazardous Substances Data: 767341-27-5(Hazardous Substances Data)

Upstream product

• 168899-58-9 3-acetoxy-2-methylbenzoic acid 
• 767341-31-1 Acetic acid 3-[(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenylsulfanyl-ethylcarbamoyl]-2-methyl-phenyl ester 

Downstream Products

• 159989-64-7 nelfinavir 

Relevant articles and documents

A short synthesis of the HIV-protease inhibitor nelfinavir via a diastereoselective addition of ammonia to the α,β-unsaturated sulfoxide derived from (R)-glyceraldehyde acetonide

Diastereoselective Michael addition of ammonia to sulfoxide 3a derived from (R)-glyceraldehyde acetonide provides amine 4a, which is converted into Nelfinavir using BF3·Et2O/NaI reduction and subsequent coupling reactions as key steps.