76748-86-2

Basic information

• Product Name: Pyranoridine phosphate
• Synonyms: PYRANORIDINE TETRAPHOSPHATE;4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno;phosphate(1:4);pyranoridinephosphate;Pyranaridine tetraphosphate;4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4);2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate
• CAS NO: 76748-86-2
• Molecular Formula: C29H44ClN5O18P4
• Molecular Weight: 910.03
• Product Categories: Inhibitor
• Mol File: 76748-86-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 233-236° (dec)
• Boiling Point: 657.2 °C at 760 mmHg
• Flash Point: 351.3 °C
• Appearance: /
• Density: 1.357g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.72
• Storage Temp.: 2-8°C
• Solubility: acetic acid: soluble5mg/mL
• CAS DataBase Reference: Pyranoridine phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Pyranoridine phosphate(76748-86-2)
• EPA Substance Registry System: Pyranoridine phosphate(76748-86-2)

Safety Data

• Hazard Codes: Xn
• Statements: 63-22-41
• Safety Statements: 26-36/37-39
• WGK Germany: 2
• RTECS: SK4920000
• Hazardous Substances Data: 76748-86-2(Hazardous Substances Data)

Usage

Uses

Pyronaridine Phosphate is an antimalarial drug.

Biological Activity

pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].

references

[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.

InChI:InChI=1/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32)