76760-24-2

Basic information

• Product Name: O-(4-nitrophenyl)inosine 5'-phosphorothioate
• CAS NO: 76760-24-2
• Molecular Weight: 485.371
• Mol File: 76760-24-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O-(4-nitrophenyl)inosine 5'-phosphorothioate(CAS DataBase Reference)
• NIST Chemistry Reference: O-(4-nitrophenyl)inosine 5'-phosphorothioate(76760-24-2)
• EPA Substance Registry System: O-(4-nitrophenyl)inosine 5'-phosphorothioate(76760-24-2)

Safety Data

• Hazardous Substances Data: 76760-24-2(Hazardous Substances Data)

Upstream product

• 4225-51-8 4-nitrophenyl dichlorothiophosphate 
• 2140-11-6 2',3'-O-isopropylideneinosine 

Downstream Products

• 76753-35-0 O-(4-aminophenyl)inosine 5'-phosphorothioate lithium salt 

Relevant articles and documents

PREPARATION OF DERIVATIVES OF INOSINE 5'-PHOSPHOROTHIOATE FOR USE IN AFFINITY CHROMATOGRAPHY

In the paper the known methods of preparation of ribonucleoside 5'-phosphorothioates II are evaluated and an improved method of their synthesis is described, based on the reaction of 2',3'-O-ethoxymethyleneribonucleosides III with thiophosphoryl chloride in the presence of one equivalent of pyridine, and subsequent hydrolysis.Inosine 5'-phosphate and inosine 5'-phosphorothioate (IIc) were converted to 2',3'-O-cyclic ketals of levulinic acid Vb, VIb on reaction with ethyl levulinate and ethyl orthoformate and subsequent alkaline hydrolysis.O-(4-Aminophenyl)inosine 5'-phosphorothioate (IX) was prepared from 2',3'-O-isopropylideneinosine (VII) with O-(4-nitrophenyl)thiophosphoryldiimidazolide and subsequent catalytic hydrogenation of the O-(4-nitrophenyl) ester VIII formed.