7677-96-5

Basic information

• Product Name: spiro[benzo[d][1,3]dioxole-2,4'-piperidine]
• Synonyms: spiro[benzo[d][1,3]dioxole-2,4'-piperidine]
• CAS NO: 7677-96-5
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• Mol File: 7677-96-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: spiro[benzo[d][1,3]dioxole-2,4'-piperidine](CAS DataBase Reference)
• NIST Chemistry Reference: spiro[benzo[d][1,3]dioxole-2,4'-piperidine](7677-96-5)
• EPA Substance Registry System: spiro[benzo[d][1,3]dioxole-2,4'-piperidine](7677-96-5)

Safety Data

• Hazardous Substances Data: 7677-96-5(Hazardous Substances Data)

Upstream product

• 923030-93-7 1'-(ethoxycarbonyl)spiro<1,3-benzodioxole-2,4'-piperidine> 
• 185316-84-1 1-(spiro[1,3-benzodioxole-2,4’-piperidine]-1-yl)ethan-1one 
• 32161-06-1 1-acetyl-4-piperidinone 
• 76360-25-3 1-(4,4-dimethoxypiperidin-1-yl)ethan-1-one 
• 120-80-9 benzene-1,2-diol 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 1456734-95-4 2-[5-bromo-3-(4-chlorobenzoyl)-4-(spiro-benzo[1,3-d]-dioxol-2-yl)-piperidin-1-ylmethyl-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-34-4 2-[3-(4-chlorobenzoyl)-4-(spiro-benzo[1,3-d]-dioxol-2-yl)-piperidin-1-ylmethyl-thiophen-2-yl]-isoindole-1,3-dione 
• 1027492-97-2 (2-amino-4-(((spiro-benzo[1,3-d]-dioxol-2-yl)-piperidin-1-yl)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone 

Relevant articles and documents

Novel tricyclic spiropiperidines. Synthesis and adrenergic activity of spiro[1,3-benzodioxolopiperidines] and spiro[1,3-benzodioxanepiperidines]

The synthesis of new series of spiropiperidines is reported. Some of these compounds showed interesting adrenergic activity. The biological activities of the new compounds were evaluated on-guinea pig atria (pi), guinea-pig trachea (β2) and rat vas deferens (a). Compounds 6a, 6c and 6f showed activity comparable to propranolol, in spite of being tertiary amines.

Piperidine derivatives having anxiolytic effect

Piperidine compounds having the general formula (I), STR1 wherein R 1 is a group having general formula (II), STR2 wherein X is CHR 10, O, S, SO, SO 2 or NR 10, Z 1 is CH 2, O, or S; Z 2 and Z 3 are independently (CH 2) n, n being 0 or 1, O or S or Z 1 and Z 2 may together represent a group --CH CH--; or when Z 3 is (CH 2) n wherein n is 0, Z 1 and Z 2 may together represent a 3-membered divalent group; show potent sigma receptor activity. Furthermore they show effect in animal models indicative of anxiolytic properties. Accordingly they are useful as medicines for the treatment of anxiety, psychosis, epilepsy, convulsion, movement disorders, motor disturbances, amnesia, cerebrovascular diseases, senile demential of the Alzheimer type or Parkinson''s disease.