76777-53-2Relevant articles and documents
New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity
Chimichi, Stefano,Boccalini, Marco,Cosimelli, Barbara,Dall'Acqua, Francesco,Viola, Giampietro
, p. 5215 - 5223 (2007/10/03)
A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety.