76793-03-8

Basic information

• Product Name: 1,3,3-trimethyl-6-(morpholin-4-yl)-2-oxabicyclo[2.2.2]octan-5-ol
• CAS NO: 76793-03-8
• Molecular Formula: C₁₄H₂₅NO₃
• Molecular Weight: 255.3532
• Mol File: 76793-03-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 361.4°C at 760 mmHg
• Flash Point: 172.4°C
• Density: 1.128g/cm³
• Vapor Pressure: 1.11E-06mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 1,3,3-trimethyl-6-(morpholin-4-yl)-2-oxabicyclo[2.2.2]octan-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,3-trimethyl-6-(morpholin-4-yl)-2-oxabicyclo[2.2.2]octan-5-ol(76793-03-8)
• EPA Substance Registry System: 1,3,3-trimethyl-6-(morpholin-4-yl)-2-oxabicyclo[2.2.2]octan-5-ol(76793-03-8)

Safety Data

• Hazardous Substances Data: 76793-03-8(Hazardous Substances Data)

Usage

General Description

1,3,3-Trimethyl-6-(morpholin-4-yl)-2-oxabicyclo[2.2.2]octan-5-ol is a chemical compound with a complicated molecular structure. It contains a bicyclic ring system with a morpholine group attached, and multiple methyl groups. 1,3,3-trimethyl-6-(morpholin-4-yl)-2-oxabicyclo[2.2.2]octan-5-ol is not widely studied or used, and there is limited information available about its properties and potential applications. However, based on its structure, it may have potential as a pharmaceutical intermediate or as a building block for organic synthesis. Further research is needed to fully understand the properties and potential uses of 1,3,3-Trimethyl-6-(morpholin-4-yl)-2-oxabicyclo[2.2.2]octan-5-ol.

Upstream product

• 31316-32-2 4-((1R,4S)-1,3,3-Trimethyl-2-oxa-bicyclo[2.2.2]oct-5-en-6-yl)-morpholine 
• 76735-26-7 1,3,3-trimethyl-6-cis-morpholino-2-oxabicyclo<2.2.2>octan-5-one 
• 76735-21-2 (1R,4S,5R,6S)-1,3,3-Trimethyl-6-morpholin-4-yl-2-oxa-bicyclo[2.2.2]octan-5-ol 

Downstream Products

• 76735-21-2 (1R,4S,5S,6S)-1,3,3-Trimethyl-6-morpholin-4-yl-2-oxa-bicyclo[2.2.2]octan-5-ol 

Relevant articles and documents

Carbonyl Transposition and Regio- and Stereo-specific Syntheses of New Alcohols, Amino-alcohols, and Ketones in the Monoterpenoid 1,3,3-Trimethyl-2-oxabicyclooctane

An efficient transposition of carbonyl group R1-CO-CH2-R2 -> R1-CH2-CO-R2 in the 1,3,3-trimethyl-2-oxabicyclooctane system was carried out via hydroboration-oxidation of 6-dialkylamino-1,3,3-trimethyl-2-oxabicyclooct-5-enes (3a-c), which gave regio- and stereo-specifically 6-cis-dialkylamino-1,3,3-trimethyl-2-oxabicyclooctan-5-trans-ols (4a-c) in high yield.Cope reaction on the N-oxide (5b) obtained from the amino-alcohol (4b) with hydrogen peroxide led to 1,3,3-trimethyl-2-oxabicyclooctan-5-one (6), the other possible isomer of the long-known 1,3,3-trimethyl-2-oxabicyclooctan-6-one (1b).The ketone (6) was also obtained from 1,3,3-trimethyl-2-oxabicyclooct-5-ene (2) via its trans-epoxide (11), lithium aluminium hydride reduction at 160-165 deg C of which gave stereo- and regio-specifically 1,3,3-trimethyl-2-oxabicyclooctan-5-trans-ol (9b).Chromic acid oxidation of (9b) and (4a-c) under various conditions gave the ketone (6) and the amino-ketones (7a-c), respectively.Lithium aluminium hydride reduction of (6) and (7a-c) afforded stereospecifically the cis-alcohol (9a) and 6-cis-dialkylamino-1,3,3-trimethyl-2-oxabicyclooctan-5-cis-ols (8a-c), respetively.Hydroboration-oxidation of the alkene (2) was not regiospecific, giving a 3:1 mixture of the trans-alcohols (9b) and (10b), respectively.