76809-56-8

Basic information

• Product Name: 2-iodo-N-(m-fluorophenyl)acetamide
• Synonyms: 2-iodo-N-(m-fluorophenyl)acetamide
• CAS NO: 76809-56-8
• Molecular Weight: 279.053
• Mol File: 76809-56-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-iodo-N-(m-fluorophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-N-(m-fluorophenyl)acetamide(76809-56-8)
• EPA Substance Registry System: 2-iodo-N-(m-fluorophenyl)acetamide(76809-56-8)

Safety Data

• Hazardous Substances Data: 76809-56-8(Hazardous Substances Data)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 350-81-2 2-chloro-N-(3-fluorophenyl)acetamide 

Downstream Products

• 1428-10-0 N-(3-fluorophenyl)formamide 
• 76810-09-8 1-(3-Fluoro-phenyl)-4-oxy-1H-pyrazin-2-one 
• 76809-90-0 N-(3-Fluoro-phenyl)-2-hydroxyamino-acetamide 
• 76809-69-3 C₁₅H₁₃FN₂O₂ 

Relevant articles and documents

Design and synthesis of novel 4'-demethyl-4-deoxypodophyllotoxin derivatives as potential anticancer agents

A group of podophyllotoxin (PPT) derivatives (7a-j) were synthesized by conjugating aryloxyacetanilide moieties to the 4'-hydroxyl of 4'-demethyl-4-deoxypodophyllotoxin (DDPT), and their anticancer activity was evaluated. It was found that the most potent compound 7d inhibited the proliferation of three cancer cell lines with sub to low micromolar IC50 values. Furthermore, it was demonstrated that 7d induced cell cycle arrest in G2/M phase in MGC-803 cells, and regulated the expression of cell cycle check point proteins, such as cyclin A, cyclin B, CDK1, cdc25c, and p21. Finally, 4 mg/kg of 7d reduced the weights and volumes of HepG2 xenografts in mice. Our findings suggest that 7d might be a potential anticancer agent.