768401-47-4Relevant articles and documents
Synthesis of enantiomerically pure α-amino-β-hydroxy- cyclobutanone derivatives and their transformations into polyfunctional three- and five-membered ring compounds
Ghosez, Léon,Yang, Gaoqiang,Cagnon, José Renato,Bideau, Franck Le,Marchand-Brynaert, Jacqueline
, p. 7591 - 7606 (2007/10/03)
Ketenes readily cycloadded to (R)-tert-butyldihydrooxazole 2a-d to yield enantiomerically pure bicyclic cyclobutanones. The cycloadditions proceeded with unusual regiochemistry giving predominantly or exclusively protected α-amino-β-hydroxycyclobutanone derivatives. The adducts could be converted into a variety of interesting enantiopure intermediates equipped with many functional groups: α-amino-β-hydroxy cyclopropane carboxylic acid derivatives, α-amino-β-hydroxy succinic acid derivatives, α-amino-β-hydroxy lactones and lactams derivatives.