76866-96-1

Basic information

• Product Name: N-(4-phenyl-4-oxobutyl)benzamide
• Synonyms: N-(4-phenyl-4-oxobutyl)benzamide
• CAS NO: 76866-96-1
• Molecular Weight: 267.327
• Mol File: 76866-96-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(4-phenyl-4-oxobutyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-phenyl-4-oxobutyl)benzamide(76866-96-1)
• EPA Substance Registry System: N-(4-phenyl-4-oxobutyl)benzamide(76866-96-1)

Safety Data

• Hazardous Substances Data: 76866-96-1(Hazardous Substances Data)

Upstream product

• 3481-02-5 cyclopropyl phenyl ketone 
• 100-47-0 benzonitrile 
• 106-39-8 bromochlorobenzene 
• 6640-25-1 4-chlorophenyl cyclopropyl ketone 
• 98-88-4 benzoyl chloride 
• 108-86-1 bromobenzene 
• 2399-66-8 1-benzoylpyrrolidin-2-one 

Relevant articles and documents

Copper(i)/Lewis acid triggered ring-opening coupling reaction of cyclopropenes with nitriles

A ring-opening coupling reaction of D-A cyclopropenes and nitriles is described for the facile synthesis of γ-amino ketones. The co-catalytic system combining copper(i) and boron trifluoride would be inspiring because it disfavors the [3 + 2] cycloadditio

Rhodium(III)-Catalyzed [3+2] Annulation of 5-Aryl-2,3-dihydro-1H-pyrroles with Internal Alkynes through C(sp2)-H/Alkene Functionalization

This study describes a new rhodium(III)-catalyzed [3+2] annulation of 5-aryl-2,3-dihydro-1H-pyrroles with internal alkynes using a Cu(OAc)2 oxidant for building a spirocyclic ring system, which includes the functionalization of an aryl C(sp2)-H bond and addition/protonolysis of an alkene C=C bond. This method is applicable to a wide range of 5-aryl-2,3-dihydro-1H-pyrroles and internal alkynes, and results in the assembly of the spiro[indene-1,2′-pyrrolidine] architectures in good yields with excellent regioselectivities.

Organometallic Ring-Opening Reactions of N-Acyl and N-Alkoxycarbonyl Lactams. Synthesis of Cyclic Imines

The reactions of hexyl- and phenylmagnesium bromides with N-acyl and N-alkoxycarbonyl lactams in tetrahydrofuran at -78 deg C have been performed to determine the factors affecting the regioselectivity.N-Pivaloyl γ- and δ-lactams undergo the ring-opening reactions with both Grignard reagents, whereas on the N-benzoyl γ-lactam a complete selectivity is achieved only with phenylmagnesium bromide.The N-Cbz γ- and δ-lactams preferentially react at the exocyclic carbonyl group, especially with hexylmagnesium bromide.The N-Boc five- to eight-membered lactams undergo the ring-opening reaction to give N-Boc-ω-amino ketones, although the efficiency slightly decreases by increasing the ring size.The deprotection of the N-Boc-ω-amino ketones with trifluoroacetic acid easily affords the corresponding five- to seven-membered cyclic imines.Pyridine alkaloids containing the cyclic imine moiety have been prepared by a modified route, exploiting the more easily available pyridyllithium reagents, instead of the corresponding Grignard reagents.