76880-30-3

Basic information

• Product Name: (R)-2-tert-Butoxycarbonylamino-3-(3-nitro-pyridin-2-yldisulfanyl)-propionic acid; compound with dicyclohexyl-amine
• CAS NO: 76880-30-3
• Molecular Weight: 556.748
• Mol File: 76880-30-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-tert-Butoxycarbonylamino-3-(3-nitro-pyridin-2-yldisulfanyl)-propionic acid; compound with dicyclohexyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-tert-Butoxycarbonylamino-3-(3-nitro-pyridin-2-yldisulfanyl)-propionic acid; compound with dicyclohexyl-amine(76880-30-3)
• EPA Substance Registry System: (R)-2-tert-Butoxycarbonylamino-3-(3-nitro-pyridin-2-yldisulfanyl)-propionic acid; compound with dicyclohexyl-amine(76880-30-3)

Safety Data

• Hazardous Substances Data: 76880-30-3(Hazardous Substances Data)

Upstream product

• 68206-45-1 3-nitro-2-pyridinesulfenyl chloride 
• 20887-95-0 N-(tert-Butyloxycarbonyl)-L-cysteine 
• 101-83-7 N-cyclohexyl-cyclohexanamine 

Relevant articles and documents

3-NITRO-2-PYRIDINESULFENYL GROUP FOR PROTECTION AND ACTIVATION OF THE THIOL FUNCTION OF CYSTEINE

The use of the 3-nitro-2-pyridinesulfenyl (Npys) halide, a versatile reagent in peptide chemistry, for the protection and activation of the thiol function is reported.Boc-Cys(Npys)-OH is prepared starting from bis(N-t-butyloxycarbonyl)-L-cystine.The Npys group is easily removed by treatment with a stoichiometric amount of tri-n-butylphosphine in the presence of water, but it is resistant to acids such as trifluoroacetic acid, HCl, and HF.Importantly, the cysteine residue modified with the Npys group can react selectively with free thiol of cysteine to afford a cystine disulfide bond.