76886-53-8Relevant articles and documents
Synthesis of Deuterium-Labeled Sesquiterpene Lactones Isolated from Inula helenium L.
Schaeffer, Marcel,Stampf, Jean-Luc,Benezra, Claude
, p. 6106 - 6113 (2007/10/02)
Reduction of the vinyl sulfoxides 9 and 10 derived from isoalantolactone (1) and alantolactone (2) with NaBD4 yielded deuterium-labeled lactones 11 and 12.Amalgam reduction of sulfides 7 and 8 or sulfoxides 9 and 10 gave labeled products but not the expected deuterated lactones 11 and 12.Satisfactory deuteration of alantolactone 2 could be achieved by CF3COOD hydrolysis of (tributylstannyl)alantolactone (23) obtained in four steps from alantolactone 2.