769-54-0

Basic information

• Product Name: 3-FLUORO-4-NITROPYRIDINE-N-OXIDE
• Synonyms: 3-fluoro-4-nitro-1$l^{5}-pyridin-1-one;3-fluoro-4-nitro-1-oxidopyridin-1-ium;3-fluoro-4-nitro-1-pyridin-1-one;3-fluoro-4-nitropyridin-1-ium-1-olate;3-FLUORO-4-NITROPYRIDINE-N-OXIDE;3-fluoro-4-nitro-, 1-oxide
• CAS NO: 769-54-0
• Molecular Formula: C₅H₃FN₂O₃
• Molecular Weight: 158.09
• EINECS: 1533716-785-6
• Product Categories: Pyridine;Pyridines;Fluorine series;alkyl Fluorine| nitro-compound
• Mol File: 769-54-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 122℃
• Boiling Point: 417.9 °C at 760 mmHg
• Flash Point: 206.5 °C
• Appearance: /
• Density: 1.56
• Vapor Pressure: 8.3E-07mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: -2.08±0.10(Predicted)
• CAS DataBase Reference: 3-FLUORO-4-NITROPYRIDINE-N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-NITROPYRIDINE-N-OXIDE(769-54-0)
• EPA Substance Registry System: 3-FLUORO-4-NITROPYRIDINE-N-OXIDE(769-54-0)

Safety Data

• Hazardous Substances Data: 769-54-0(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-nitropyridine-N-oxide is a chemical compound with the molecular formula C5H3FN2O3. It is a yellow crystalline solid that is used in the synthesis of pharmaceuticals and agrochemicals. 3-FLUORO-4-NITROPYRIDINE-N-OXIDE is known for its nitro functionality, which makes it an important building block in organic chemistry. It is also used as a reagent in the production of other chemical compounds. 3-Fluoro-4-nitropyridine-N-oxide is considered to be a potentially hazardous chemical and should be handled with care in a laboratory setting.

InChI:InChI=1/C5H3FN2O3/c6-4-3-7(9)2-1-5(4)8(10)11/h1-3H

Upstream product

• 695-37-4 3-fluoropyridine-1-oxide 
• 372-47-4 3-Fluoropyridine 
• 1678-49-5 3-Bromo-4-nitropyridine N-oxide 

Downstream Products

• 2247-88-3 3-fluoro-pyridin-4-ylamine 
• 132038-15-4 4-nitro-3-(4-methoxyphenoxy)pyridine N-oxide 
• 13959-53-0 4-nitro-3-phenoxypyridine-N-oxide 
• 73407-30-4 4-nitro-3-(2-chlorophenoxy)pyridine N-oxide 
• 69999-41-3 4-(4-nitro-1-oxy-pyridin-3-yl)-piperazine-1,3-dicarboxylic acid 1-benzyl ester 
• 941706-45-2 N-(1-Benzylpiperidin-4-yl)-4-nitropyridin-3-amine 1-oxide 
• 1330531-68-4 [2-(5-chloro-2-fluorophenyl)-[1,8]naphthyridin-4-yl]-[3-(3-morpholin-4-yl-propoxy)-pyridin-4-yl]-amine 
• 19355-04-5 3-methoxy-4-nitropyridine 1-oxide 
• 19349-73-6 3-ethoxy-4-nitropyridine-1-oxide 
• 1610521-11-3 4-bromo-3-(cyclopropylmethoxy)pyridine 
• 13505-07-2 4-nitro-3-methoxypyridine 

Relevant articles and documents

PYRAZINE COMPOUND

PROBLEM TO BE SOLVED: To provide a compound showing improved control activity on various pests or its salt. SOLUTION: The present invention provides a pyrazine compound having a 4-pyridyl group represented by formula (1) or its salt. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Synthesis of: Meta -substituted [18F]3-fluoro-4-aminopyridine via direct radiofluorination of pyridine N -oxides

Due to their electron-rich aromatic structure, nucleophilic (radio)fluorination of pyridines is challenging, especially at the meta position. In this paper, we describe the first example of direct fluorination of a pyridine N-oxide to produce a meta fluorinated pyridine. Specifically, fluorination of 3-bromo-4-nitropyridine N-oxide produced in several minutes 3-fluoro-4-nitropyridine N-oxide in moderate yield at room temperature. This intermediate compound was later converted to 3-fluoro-4-aminopyridine easily by catalytic hydrogenation. Furthermore, this approach was successfully applied for labeling with fluorine-18. The use of pyridine N-oxides for the preparation of fluoropyridines is unprecedented in the chemical literature and has the potential to offer a new way for the synthesis of these important structures in pharmaceuticals and radiopharmaceuticals.

Chemical compounds

Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).