769158-10-3

Basic information

• Product Name: 2-((2,7-dichloro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile
• Synonyms: 2-((2,7-dichloro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile
• CAS NO: 769158-10-3
• Molecular Weight: 330.173
• Mol File: 769158-10-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((2,7-dichloro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((2,7-dichloro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile(769158-10-3)
• EPA Substance Registry System: 2-((2,7-dichloro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile(769158-10-3)

Safety Data

• Hazardous Substances Data: 769158-10-3(Hazardous Substances Data)

Upstream product

• 20197-96-0 2,7-dichloro-3,4-dihydro-4-oxoquinazoline 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 13165-35-0 7-chloroquinazoline-2,4-dione 
• 6625-94-1 2,4,7-trichloroquinazoline 

Relevant articles and documents

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Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4). Herein, we describe the structure-based design and optimization of alogliptin and related quinazolinone-based DPP-4 inhibitors. Following an oral dose, these noncovalent inhibitors provide sustained reduction of plasma DPP-4 activity and a lowering of blood glucose in animal models of diabetes. Alogliptin is currently undergoing phase 111 trials in patients with type 2 diabetes.