76982-22-4

Basic information

• Product Name: 2,5-Piperazinedione, 1,4-diacetyl-3-(phenylmethyl)-, (S)-
• CAS NO: 76982-22-4
• Molecular Formula: C15H16N2O4
• Molecular Weight: 288.303
• Mol File: 76982-22-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,5-Piperazinedione, 1,4-diacetyl-3-(phenylmethyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Piperazinedione, 1,4-diacetyl-3-(phenylmethyl)-, (S)-(76982-22-4)
• EPA Substance Registry System: 2,5-Piperazinedione, 1,4-diacetyl-3-(phenylmethyl)-, (S)-(76982-22-4)

Safety Data

• Hazardous Substances Data: 76982-22-4(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 30166-29-1 1-acetyl-3-[(Z)-benzylidene]-2,5-piperazinedione 
• 3027-05-2 N,N'-diacetylpiperazin-2,5-dione 
• 5037-75-2 cyclo(Gly-Phe) 
• 65559-51-5 L-Phenylalaninyl-glycine methyl ester 
• 7625-57-2 methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetate 

Downstream Products

• 1235977-31-7 t-butyl-3-[(3S)-(Z)-(5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate 
• 1235977-30-6 t-butyl-3-[(3S)-(Z)-(4-acetyl-5-benzyl-3,6-dioxopiperazin-2-ylidene)methyl]-4-nitroindole-1-carboxylate 
• 1092687-10-9 1-acetyl-6-benzyl-3-(2-bromobenzylidene)piperazine-2,5-dione 
• 77027-33-9 4-acetyl-(S)-3-benzyl-(E)-6-benzylidene-2,5-piperazinedione 
• 117249-51-1 (R)-3-benzyl-(Z)-6-benzylidene-2,5-piperazinedione 
• 77027-29-3 4-acetyl-(S)-3-benzyl-(Z)-6-benzylidene-2,5-piperazinedione 

Relevant articles and documents

Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation

Alzheime?s disease (AD) is the most prominent neurodegenerative disorder with high medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where β-amyloid structures (Aβ) build toxic oligomers. Design of disease modifying multi target directed ligand (MTDL) has been performed, which disable PPI on the one hand and on the other hand, act as procognitive antagonists at the histamine H3 receptor (H3R). The synthetized compounds are structurally based on peptidomimetic amino acid-like structures mainly as keto, diketo-, or acyl variations of a piperazine moiety connected to an H3R pharmacophore. Most of them showed low nanomolar affinities at H3R and some with promising affinity to Aβ-monomers. The structure–activity relationships (SAR) described offer new possibilities for MTDL with an optimized profile combining symptomatic and potential causal therapeutic approaches in AD.

Herbicidally Active Composition

The present invention relates to herbicidally active compositions comprising at least one piperazinedione compound of the formula I in which: Rx, Ry are each hydrogen or together are a chemical bond; R1 is cyano or nitro; R2 is hydrogen, fluorine, chlorine, C1-C2-alkyl, ethenyl or C1-C2-alkoxy; R3 is fluorine or hydrogen; R4 is methyl; R5 is hydrogen, methyl or ethyl; R6 is hydrogen, methyl or ethyl; and R7 is hydrogen or halogen; and at least one further active compound selected from the group consisting of b1) lipid biosynthesis inhibitors; b2) acetolactate synthase inhibitors (ALS inhibitors); b3) photosynthesis inhibitors; b4) protoporphyrinogen-IX oxidase inhibitors, b5) bleacher herbicides; b6) enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors); b7) glutamine synthetase inhibitors; b8) 7,8-dihydropteroate synthase inhibitors (DHP inhibitors); b9) mitose inhibitors; b10) inhibitors of the synthesis of very long chain fatty acids (VLCFA inhibitors); b11) cellulose biosynthesis inhibitors; b12) decoupler herbicides; b13) auxin herbicides; b14) auxin transport inhibitors; b15) other herbicides, and C) safeners.

Synthesis and biological activities of phenylahistin derivatives

X-ray crystallographic analysis was performed and several phenylahistin derivatives were synthesized to elucidate the structural components necessary for the anti-microtubule activity of phenylahistin. We primarily focused on the unique isoprenylated dehy