769968-17-4Relevant articles and documents
Regioselective 15-bromination and functionalization of a stable synthetic bacteriochlorin
Fan, Dazhong,Taniguchi, Masahiko,Lindsey, Jonathan S.
, p. 5350 - 5357 (2007)
(Chemical Equation Presented) 5-Methoxy-8,8,18,18-tetramethyl-2,12-di-p- tolylbacteriochlorin (MeO-BC) undergoes regioselective electrophilic bromination with NBS to give the 15-bromo analogue (MeO-BC-Br15) in 85% yield. By contrast, the bacter
GPR35 MODULATORS
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, (2020/08/13)
Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins
Pérez-Perarnau, Alba,Preciado, Sara,Palmeri, Claudia Mariela,Moncunill-Massaguer, Cristina,Iglesias-Serret, Daniel,González-Gironès, Diana M.,Miguel, Miriam,Karasawa, Satoki,Sakamoto, Satoshi,Cosialls, Ana M.,Rubio-Pati?o, Camila,Saura-Esteller, José,Ram?n, Rosario,Caja, Laia,Fabregat, Isabel,Pons, Gabriel,Handa, Hiroshi,Albericio, Fernando,Gil, Joan,Lavilla, Rodolfo
supporting information, p. 10150 - 10154 (2015/03/31)
A new class of small molecules, with an unprecedented trifluorothiazoline scaffold, were synthesized and their pro-apoptotic activity was evaluated. With an EC50 in the low micromolar range, these compounds proved to be potent inducers of apopt