77-04-3

Basic information

• Product Name: Pyrithyldione
• Synonyms: 3,3-Diethyl-2,4(1H,3H)-pyridinedione; 3,3-diethylpyridine-2,4(1H,3H)-dione
• CAS NO: 77-04-3
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.205
• EINECS: 201-000-5
• Product Categories: PERSEDON
• Mol File: 77-04-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 92-93°; mp 97-98°; mp 81-86° [Scheibl, Wachter, Arch. Toxikol. 18, 253 (1960)]
• Boiling Point: 330.2°C at 760 mmHg
• Flash Point: 147.8°C
• Density: 1.029g/cm³
• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.464
• Storage Temp.: Room Temperature
• Solubility: Dichloromethane; Ethyl Acetate; Methanol
• PKA: 11.69±0.40(Predicted)
• CAS DataBase Reference: Pyrithyldione(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrithyldione(77-04-3)
• EPA Substance Registry System: Pyrithyldione(77-04-3)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21:Harmful by inhalation and in contact with skin.
• Safety Statements: S23:Do not inhale gas/fumes/vapour/spray.
• Hazardous Substances Data: 77-04-3(Hazardous Substances Data)

Usage

Description

Pyrithyldione, also known as Pyridione, is a white fine crystalline or powdery substance with chemical properties that make it a valuable intermediate in the pharmaceutical industry. It is primarily recognized for its role in the synthesis of sedative and hypnotic drugs, specifically Methyprylon (M338670), which is used for treating insomnia.

Uses

Used in Pharmaceutical Industry:
Pyrithyldione is used as an intermediate in the synthesis of sedative/hypnotic drugs for the treatment of insomnia. Its chemical properties allow it to be a crucial component in the creation of Methyprylon (M338670), a medication that helps alleviate sleep disorders and promotes restful sleep.
Additionally, Pyrithyldione is used as a hypnotic and sedative agent in the pharmaceutical industry. Its calming effects make it a valuable asset in the development of medications aimed at reducing anxiety and promoting relaxation.

Upstream product

• 74367-91-2 2,2-diethyl-5-amino-3-oxo-pent-4-enoic acid ethyl ester 
• 1619-57-4 ethyl 2,2-diethyl-3-oxobutanoate 

Downstream Products

• 20096-03-1 3,3-diethyl-5-hydroxymethyl-1H-pyridine-2,4-dione 
• 110462-09-4 3,3-diethyl-6-benzyl-piperidine-2,4-dione 
• 107055-55-0 3,3-diethyl-6-phenyl-piperidine-2,4-dione 
• 1130-18-3 N-Methyl-2,4-dioxo-3,3-diethyl-1,2,3,4-tetrahydropyridin 
• 77-03-2 3,3-diethyl-piperidine-2,4-dione 
• 23192-94-1 2,4-Dioxo-1-morpholinomethyl-3,3-diethyl-tetrahydropyridin 
• 253170-63-7 1-(2-bromo-benzoyl)-3,3-diethyl-1H-pyridine-2,4-dione 
• 131728-20-6 N-(phenyl)-N-[1-(2-(1,2,3,4-tetrahydro-2,4-dioxo-3,3-diethylpyridin-1-yl)-ethyl)-4-methoxymethyl-4-piperidinyl]propanamide 
• 131728-18-2 N-(phenyl)-N-[1-(2-(1,2,3,4-tetrahydro-2,4-dioxo-3,3-diethylpyridin-1-yl)-ethyl)-4-methoxycarbonyl-4-piperidinyl]propanamide 
• 467-90-3 3,3-diethyl-5-methyl-1H-pyridine-2,4-dione 
• 125-64-4 methyprylon 

Relevant articles and documents

A simple synthetic protocol for the protection of amides, lactams, ureas, and carbamates

A new procedure for protecting the amide, lactam, urea, and carbamate NH group with a triphenylmethyl (Tr) group is described. The utility of this method is illustrated with molecules that contain other functional groups. A mild deprotection using trifluoroacetic acid makes this a useful method for attaching amide groups on resin for combinatorial synthesis.