77078-72-9

Basic information

• Product Name: Cyclohexanone, 2,6-bis(1,1-dimethylethyl)-, (2R,6S)-rel-
• CAS NO: 77078-72-9
• Molecular Formula: C14H26O
• Molecular Weight: 210.36
• Mol File: 77078-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 2,6-bis(1,1-dimethylethyl)-, (2R,6S)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2,6-bis(1,1-dimethylethyl)-, (2R,6S)-rel-(77078-72-9)
• EPA Substance Registry System: Cyclohexanone, 2,6-bis(1,1-dimethylethyl)-, (2R,6S)-rel-(77078-72-9)

Safety Data

• Hazardous Substances Data: 77078-72-9(Hazardous Substances Data)

Upstream product

• 128-39-2 2,6-di-tert-butylphenol 
• 507-20-0 tertiary butyl chloride 
• 76509-04-1 6-(tert-butyl)-1-trimethylsilyloxy-cyclohexene 

Downstream Products

• 71285-12-6 cis-2,6-Di-tert-butyl-1-methylcyclohexanol 
• 100962-76-3 2t,6t-di-tert-butyl-cyclohexan-r-ol 
• 100962-76-3 cis,cis-2,6-di-tert-butylcyclohexanol 
• 100962-76-3 (+/-)-2r,6t-Di-tert-butyl-cyclohexanol 

Relevant articles and documents

Lewis Acid Mediated α-Alkylation of Carbonyl Compounds, VII. Regio and Position Specific α-tert-Alkylation of Ketones

Structurally different ketones can be alkylated at the α-position via their silyl enol ethers with tert-alkyl halides in the presence of Lewis acids such as titanium tetrachloride (->27 - 35).Concerning the alkylation agent, the position specific introduction of branched and cyclic tert-alkyl groups is possible (->41 - 49).Bridgehead halides of the type 1-adamantyl bromide react analogously (->52 - 61).Silyl enol ethers derived from unsymmetrical ketones react regiospecifically (->63, 64, 66, 67).If the reaction partners contain additional functional groups such as aryl residues (->68, 69) or ester groups (->71) or primary alkyl halides moieties (->73), selectivity in the desired manner is observed. α,α'-Bis-tert-alkylated ketones (74 - 76) are also easily accessible, but not the α,α-isomers.