77082-31-6 Usage
Description
2-Phenyl-thiomorpholine, with the molecular formula C12H17S, is a cyclic sulfur-containing organic compound characterized by a morpholine ring and a phenyl group attached. This versatile chemical serves as a key building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It also plays a significant role as a reagent in organic chemistry for the formation of carbon-sulfur bonds and as a chelating agent in metal ion coordination chemistry. Moreover, 2-phenyl-thiomorpholine has demonstrated potential biological activity, making it a subject of interest for research in medicinal and pharmaceutical fields.
Uses
Used in Pharmaceutical Industry:
2-Phenyl-thiomorpholine is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows it to be a valuable component in the creation of molecules with specific medicinal properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Phenyl-thiomorpholine is utilized as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its ability to form carbon-sulfur bonds makes it a crucial element in the development of effective and targeted agrochemical products.
Used in Organic Chemistry:
2-Phenyl-thiomorpholine serves as a reagent in organic chemistry, particularly for the formation of carbon-sulfur bonds. This capability is essential in the synthesis of a wide range of organic compounds, expanding the scope of chemical reactions and products that can be achieved.
Used in Metal Ion Coordination Chemistry:
As a chelating agent, 2-Phenyl-thiomorpholine is used in metal ion coordination chemistry to form stable complexes with metal ions. This application is vital in various fields, including catalysis, material science, and environmental remediation, where the selective binding and manipulation of metal ions are required.
Used in Medicinal and Pharmaceutical Research:
Due to its potential biological activity, 2-Phenyl-thiomorpholine is studied for its possible use in medicinal and pharmaceutical fields. Researchers are exploring its properties to understand its potential as a therapeutic agent or as a component in the development of new drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 77082-31-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,0,8 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 77082-31:
(7*7)+(6*7)+(5*0)+(4*8)+(3*2)+(2*3)+(1*1)=136
136 % 10 = 6
So 77082-31-6 is a valid CAS Registry Number.
77082-31-6Relevant articles and documents
HETEROCYCLIC COMPOUNDS
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Paragraph 0203, (2020/12/29)
Provided herein are compounds of formula (I) which comprise a thiomorpholine 1,1-dioxide or 1-imino-thiomorpholine 1-oxide moiety, or pharmaceutically acceptable salts of any of the foregoing, pharmaceutical compositions that include a compound described herein (including salts of the compound) and methods of synthesizing the same. Also provided are methods of treating Hepatitis B viral (HBV) infections using a compound of formula (I), or pharmaceutically acceptable salts thereof.
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors
Lühr, Susan,Vilches-Herrera, Marcelo,Fierro, Angélica,Ramsay, Rona R.,Edmondson, Dale E.,Reyes-Parada, Miguel,Cassels, Bruce K.,Iturriaga-Vásquez, Patricio
experimental part, p. 1388 - 1395 (2010/05/17)
2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided insight into the binding mode of these inhibitors and rationalized their different potencies. Making the phenylethylamine scaffold rigid by fixing the amine chain in an extended six-membered ring conformation increased MAO-B (but not MAO-A) inhibitory activity relative to the more flexible α-methylated derivative. The presence of a basic nitrogen atom is not a prerequisite in either MAO-A or MAO-B. The best Ki values were in the 10-8 M range, with selectivities towards human MAO-B exceeding 2000-fold.
