77093-97-1

Basic information

• Product Name: 3-(2-Methoxyethyl)-2,4(1H,3H)-Quinazolinedione
• Synonyms: 3-(2-Methoxyethyl)-2,4(1H,3H)-Quinazolinedione;3-(2-Methoxyethyl)quinazoline-2,4(1H,3H)-dione
• CAS NO: 77093-97-1
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.22458
• EINECS: -0
• Mol File: 77093-97-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(2-Methoxyethyl)-2,4(1H,3H)-Quinazolinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Methoxyethyl)-2,4(1H,3H)-Quinazolinedione(77093-97-1)
• EPA Substance Registry System: 3-(2-Methoxyethyl)-2,4(1H,3H)-Quinazolinedione(77093-97-1)

Safety Data

• Hazardous Substances Data: 77093-97-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 52727-44-3 2,3-dihydro-5H-oxazolo<2,3-b>quinazolin-5-one 
• 13908-44-6 2-<3-(2-chloroethyl)ureido>benzoic acid 
• 77189-70-9 2-<3-(2-cloroethyl)ureido>benzonitrile 
• 77093-94-8 2-(2-chloroethylamino)-4H-<3,1>benzoxazin-4-one hydrochloride 
• 77093-93-7 2-(2-chloroethylamino)-4H-<3,1>benzoxazin-4-one 
• 77093-92-6 methyl 2-<3-(2-chloroethyl)ureido>benzoate 
• 118-92-3 anthranilic acid 
• 134-20-3 2-carbomethoxyaniline 
• 5081-87-8 3-(2-chloroethyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 
• 1885-29-6 anthranilic acid nitrile 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 109-85-3 2-methoxyethylamine 
• 118-48-9 isatoic anhydride 

Relevant articles and documents

1,3,4-OXADIAZOLE HOMOPHTHALIMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a medicinal use thereof, and a method for preparing the same. The novel compounds according to the present invention, stereoisomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; endocrinopathy; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, or chromosomal aberration.

Reactions of o-Aminonitriles with Isocyanates. 1. A Two-Step Synthesis of 2,6-Dihydroimidazoquinazolin-5-(3H)one

The reaction of anthranilonitrile with 2-chloroethyl isocyanate yields 2-benzonitrile (6) which, upon heating, or treatment with base, undergoes a double cyclization to form 2,6-dihydroimidazoquinazolin-5-(3H)one (8) in excellent yield.When heated with hydrochloric acid, 6 is converted initially into 2-(2-chloroethylamino)-4H-benzoxazin-4-one (18) and further into 3-(2-chloroethyl)-2,4-(1H,3H)quinazolinedione (15).The acid-catalyzed reaction of 2,3-dihydro-5H-oxazoloquinazolin-5-one (14) with nucleophilic reagents yields 3-substituted 2,4-(1H,3H)quinazolinediones.