77124-59-5Relevant articles and documents
Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties
Sablayrolles,Cros,Milhavet,Rechenq,Chapat,Boucard,Serrano,McNeill
, p. 206 - 212 (2007/10/02)
A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.
Research on heterocyclic compounds. X - Imidazo[1,2-a]pyrazine derivatives: synthesis and antiinflammatory activity
Abignente,Arena,de Caprariis,Nuzzetti,Marmo,Lampa,Rosatti,Ottavo
, p. 61 - 80 (2007/10/02)
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