77141-07-2

Basic information

• Product Name: (S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• CAS NO: 77141-07-2
• Molecular Weight: 222.2
• Mol File: 77141-07-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(77141-07-2)
• EPA Substance Registry System: (S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(77141-07-2)

Safety Data

• Hazardous Substances Data: 77141-07-2(Hazardous Substances Data)

Upstream product

• 74163-81-8 L-Tic-OH 

Downstream Products

• 236429-63-3 7-amino-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 

Relevant articles and documents

A convenient synthesis of N-Fmoc-N,N′-bis-Boc-7-guanyl-1,2,3,4-tetrahydro-isoquinoline-3- carboxylic acid (Fmoc-N,N′-bis-Boc-7-guanyl-Tic-OH, GTIC)

Fmoc-N,N′-Bis-Boc-7-guanyl-Tic-OH (GTIC), a conformationally constrained amino acid with basic properties, has been synthesized in four steps. This amino acid can be incorporated into peptides using standard Fmoc solid phase synthesis, and to test its potential for biological activity applications, we prepared an analog of H-Dmt-Tic-NH2.

BIOREVERSABLE PROMOIETIES FOR NITROGEN-CONTAINING AND HYDROXYL-CONTAINING DRUGS

Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent: (I) and pharmaceutical compositions comprising the prodrugs.

1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors

High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline sca