771543-90-9

Basic information

• Product Name: cis-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester
• Synonyms: cis-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester
• CAS NO: 771543-90-9
• Molecular Weight: 349.476
• Mol File: 771543-90-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cis-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: cis-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester(771543-90-9)
• EPA Substance Registry System: cis-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester(771543-90-9)

Safety Data

• Hazardous Substances Data: 771543-90-9(Hazardous Substances Data)

Upstream product

• 247570-24-7 tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate 
• 34171-43-2 2-chloro-4-dimethylamino-5-methylpyrimidine 

Downstream Products

• 771543-91-0 cis-4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-4-aminocyclohexane 
• 771545-70-1 cis-2-bromo-N-[4-(4-dimethylamino-5-methyl-pyrimidin-2-ylamino)-cyclohexyl]-acetamide 

Relevant articles and documents

Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: In vitro profiling and in vivo evaluation

A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro. Significantly improved receptor selectivity was achieved with several analogues from this series, but no improvement in brain partitioning was noted. One example from this series was shown to inhibit food intake and decrease body weight in a chronic study. However no clear correlation between the pharmacodynamic effect and the pharmacokinetic data with respect to brain concentration was discernible leading us to conclude that the observed effect was most likely not due to interaction with the MCH-R1.