77156-78-6

Basic information

• Product Name: ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE
• Synonyms: ETHYL 4-HYDROXY-6-METHOXY-3-QUINOLINECARBOXYLATE;ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE;BUTTPARK 20\09-61;4-HYDROXY-6-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;Ethyl 1,4-dihydro-6-methoxy-4-oxoquinoline-3-carboxylate;Ethyl 6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate;4-Hydroxy-6-methoxy-3-quinolinecarboxylic acid ethyl ester;4-keto-6-methoxy-1H-quinoline-3-carboxylic acid ethyl ester
• CAS NO: 77156-78-6
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.25
• EINECS: -0
• Product Categories: blocks;Carboxes;Quinolines
• Mol File: 77156-78-6.mol
• Article Data: 21

Chemical Properties

• Melting Point: 280-283℃
• Boiling Point: 394.7oC at 760 mmHg
• Flash Point: 192.5oC
• Appearance: /
• Density: 1.277
• Vapor Pressure: 1.95E-06mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.72±0.50(Predicted)
• CAS DataBase Reference: ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE(77156-78-6)
• EPA Substance Registry System: ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE(77156-78-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 77156-78-6(Hazardous Substances Data)

Usage

General Description

ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE is a chemical compound that belongs to the quinoline family. It is a derivative of quinoline with a hydroxy and methoxy group at the 4th and 6th position, respectively, and a carboxylate group at the 3rd position. ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE is commonly used in the pharmaceutical industry for its potential medicinal properties, particularly for its antioxidant and anti-inflammatory effects. It has also been studied for its potential use in the treatment of various diseases and conditions, including cancer, neurodegenerative disorders, and infectious diseases. Overall, ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE is a compound of interest for its potential therapeutic applications.

InChI:InChI=1/C13H13NO4/c1-3-18-13(16)10-7-14-11-5-4-8(17-2)6-9(11)12(10)15/h4-7H,3H2,1-2H3,(H,14,15)

Upstream product

• 83507-70-4 diethyl 2-(((4-methoxyphenyl)amino)methylene)malonate 
• 104-94-9 4-methoxy-aniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 142892-71-5 diethyl 2-[amino(4-methoxyphenyl)methylene]malonate 
• 22931-71-1 ethyl 4-chloro-6-methoxyquinolin-3-carboxylate 

Downstream Products

• 28027-16-9 4-hydroxy-6-methoxy-3-quinoline carboxylic acid 
• 22931-71-1 ethyl 4-chloro-6-methoxyquinolin-3-carboxylate 
• 104406-72-6 N-(β-phenethyl)-4-hydroxy-6-methoxyquinoline-3-carboxamide 
• 23432-39-5 4-hydroxy-6-methoxyquinoline 
• 148018-29-5 4-chloro-quinolin-6-ol 
• 860205-96-5 4-anilino-6-methoxy-quinoline-3-carboxylic acid 
• 77157-28-9 4-anilino-6-methoxy-quinoline-3-carboxylic acid ethyl ester 
• 872714-50-6 4-bromo-6-methoxy-quinoline-3-carboxylic acid ethyl ester 
• 933710-66-8 4-amino-6-methoxyquinoline-3-carboxylic acid 
• 908350-29-8 ethyl 4-amino-6-methoxyquinoline-3-carboxylate 
• 1598416-84-2 6-methoxy-4-(2-(4-(4-nitrobenzylamino)piperidin-1-yl)ethyl)quinoline-3-carbonitrile 
• 1598416-85-3 4-(2-(4-(4-hydroxy-3-methoxybenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile 
• 1598416-86-4 4-(2-(4-(4-fluoro-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile 
• 1598416-87-5 6-methoxy-4-(2-(4-(3-nitrobenzylamino)piperidin-1-yl)ethyl)quinoline-3-carbonitrile 

Relevant articles and documents

SUBSTITUTED QUINOLINE ANALOGS AS ALDEHYDE DEHYDROGENASE 1A1 (ALDH1A1) INHIBITORS

The disclosure provides compounds of Formula I, which may be useful as aldehyde dehydrogenase inhibitors and the pharmaceutically acceptable salts thereof. The variables, J, R4, G, Q, and ring A are defined herein. Aldehyde dehydrogenase inhibitors of Formula I are useful for treating a variety of conditions including cancer and inflammation. The disclosure includes methods for using compounds and salts of Formula I to treat colon cancer, pancreatic cancer, nasopharyngeal carcinoma, thyroid cancer, prostate cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, hepatocellular carcinoma, leukemia, brain tumorsbreast cancer, atherosclerosis, ischaemic heart disease, acne vulgaris, asthma, autoimmune diseases, autoinflammatory diseases, chronic prostatitis, glomerulonephritis, inflammatory bowel disease, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, sarcoidosis, transplant rejection, vasculitis, and interstitial cystitis. The disclosure also includes pharmaceutical compositions containing a compound or salt of Formula I.

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER

The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

INHIBITORS OF DNA GYRASE FOR THE TREATMENT OF BACTERIAL INFECTIONS

The present invention relates to compounds which specifically inhibit bacterial DNA Gyrase and can be used for the treatment of respiratory tract infections.