771566-03-1

Basic information

• Product Name: 2-(5-benzyloxy-1H-pyrrolo[2,3-c]pyridin-3-ylmethylene)-malononitrile
• Synonyms: 2-(5-benzyloxy-1H-pyrrolo[2,3-c]pyridin-3-ylmethylene)-malononitrile
• CAS NO: 771566-03-1
• Molecular Weight: 300.319
• Mol File: 771566-03-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-benzyloxy-1H-pyrrolo[2,3-c]pyridin-3-ylmethylene)-malononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-benzyloxy-1H-pyrrolo[2,3-c]pyridin-3-ylmethylene)-malononitrile(771566-03-1)
• EPA Substance Registry System: 2-(5-benzyloxy-1H-pyrrolo[2,3-c]pyridin-3-ylmethylene)-malononitrile(771566-03-1)

Safety Data

• Hazardous Substances Data: 771566-03-1(Hazardous Substances Data)

Upstream product

• 56795-92-7 1H-Pyrrolo<2,3-c>pyridine-3-carbaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: Parallel synthesis, bioactivity, and in vitro pharmacokinetics

2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-negative prion protein mutants and inhibit prion replication in cultured cells. Here, we report findings from a comprehensive structure-activity relationship study of the 6-aminopyridine-3,5-dicarbonitrile scaffold. We identify compounds with significantly improved bioactivity (approximately 40-fold) against replication of the infectious prion isoform (PrPSc) and suitable pharmacokinetic profiles to warrant evaluation in animal models of prion disease.