77191-37-8

Basic information

• Product Name: 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid
• Synonyms: 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid;oxiracetaM related substance ISF3138;1-Pyrrolidineacetic acid, 4-hydroxy-2-oxo-;2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetic acid;OxiracetaM IMp.ISF3138;(4-Hydroxy-2-oxo-1-pyrrolidinyl)acetic acid;OxiracetaM iMpurity B;Oxiracetam Impurity 7
• CAS NO: 77191-37-8
• Molecular Formula: C₆H₉NO₄
• Molecular Weight: 159.14
• Product Categories: Oxiracetam
• Mol File: 77191-37-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 465.565 °C at 760 mmHg
• Flash Point: 235.365 °C
• Appearance: /
• Density: 1.508
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• PKA: 3.75±0.10(Predicted)
• CAS DataBase Reference: 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid(77191-37-8)
• EPA Substance Registry System: 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid(77191-37-8)

Safety Data

• Hazardous Substances Data: 77191-37-8(Hazardous Substances Data)

Usage

Description

4-Hydroxy-2-oxo-1-pyrrolidineacetic acid, also known as 1-Pyrrolidineacetic acid, is a derivative of Oxiracetam, a nootropic compound. It is structurally similar to Piracetam and possesses psychostimulant activity. This molecule is characterized by its potential cognitive-enhancing properties and its ability to stimulate the central nervous system.

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-2-oxo-1-pyrrolidineacetic acid is used as a nootropic agent for enhancing cognitive functions and memory. Its psychostimulant activity makes it a promising candidate for the development of drugs aimed at improving brain performance and treating cognitive disorders.
Used in Cognitive Enhancement:
4-Hydroxy-2-oxo-1-pyrrolidineacetic acid is used as a cognitive enhancer to improve memory, learning, and focus. Its psychostimulant properties may help in increasing alertness and attention, making it a potential candidate for the treatment of attention deficit disorders and other cognitive impairments.
Used in Research and Development:
In the field of neuroscience and pharmaceutical research, 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid serves as a valuable compound for studying the mechanisms underlying cognitive enhancement and the development of novel therapeutic strategies for neurological and psychiatric conditions.

InChI:InChI=1/C6H9NO4/c8-4-1-5(9)7(2-4)3-6(10)11/h4,8H,1-3H2,(H,10,11)

Upstream product

• 62613-80-3 1-ethoxycarbonylmethylpyrrolidine-2,4-dione 
• 62613-81-4 ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate 
• 142274-11-1 2,4-dioxopyrrolidin-1-yl-acetic acid 
• 142352-10-1 (2,4-dioxopyrrolidin-1-yl)acetamide hydrochloride 
• 114012-62-3 (1,5-dihydro-4-methoxy-2-oxo-2H-pyrrol-1-yl)acetamide 
• 142274-08-6 (4-ethoxy-1,5-dihydro-2-oxo-2H-pyrrol-1-yl)acetic acid 
• 110104-61-5 ethyl (2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl)acetate 
• 68252-28-8 oxiracetam 

Downstream Products

• 62613-81-4 ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate 
• 99437-11-3 ((S)-4-hydroxy-2-oxopyrrolidin-1-yl)acetic acid 

Relevant articles and documents

Preparation method and application of 4-hydroxy-2-oxo-1-pyrrolidine acetic acid

The invention provides a preparation method of 4-hydroxy-2-oxo-1-pyrrolidine acetic acid, and the preparation method comprises the following steps: mixing oxiracetam and a lithium compound to react, so as to obtain the 4-hydroxy-2-oxo-1-pyrrolidine acetic acid. The preparation method provided by the invention is simple to operate, high in yield, high in purity and simple and convenient in post-treatment.

An efficient synthesis of racemic 4-hydroxy-2-oxo-1-pyrrolidineacetamide (oxiracetam) using tetramic-acid intermediates

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