772-67-8

Basic information

• Product Name: 2-Butanone, 1-fluoro-4-phenyl-
• Synonyms: 2-Butanone, 1-fluoro-4-phenyl-
• CAS NO: 772-67-8
• Molecular Formula: C₁₀H₁₁FO
• Molecular Weight: 166.19
• Mol File: 772-67-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Butanone, 1-fluoro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 1-fluoro-4-phenyl-(772-67-8)
• EPA Substance Registry System: 2-Butanone, 1-fluoro-4-phenyl-(772-67-8)

Safety Data

• Hazardous Substances Data: 772-67-8(Hazardous Substances Data)

Upstream product

• 3277-89-2 phenethylmagnesium bromide 
• 459-72-3 ethyl 2-fluoroacetate 
• 100-39-0 benzyl bromide 
• 99687-73-7 fluoroacetone cyclohexylimine 
• 114156-08-0 fluoroacetone cyclohexylimine 
• 503-20-8 fluoroacetonitrile 
• 103-63-9 1-phenyl-2-bromoethane 
• 1035814-78-8 1-fluoro-4-phenylbutan-2-ol 
• 373-53-5 fluoroiodomethane 
• 170646-96-5 N-methoxy-N-methyl-3-phenylpropionamide 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 1035814-78-8 1-fluoro-4-phenylbutan-2-ol 
• 110229-72-6 Acetic acid 1-fluoromethyl-3-phenyl-propyl ester 
• 1415315-19-3 C₁₄H₁₉F 
• 1415314-89-4 C₁₂H₁₅FO 
• 1415314-84-9 C₁₄H₁₇FO₂ 
• 1541177-56-3 1-fluoro-4-phenyl-2-((trimethylsilyl)methyl)butan-2-ol 

Relevant articles and documents

Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors

The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics.

Toward a Unified Mechanism for Oxoammonium Salt-Mediated Oxidation Reactions: A Theoretical and Experimental Study Using a Hydride Transfer Model

A range of oxoammonium salt-based oxidation reactions have been explored computationally using density functional theory (DFT), and the results have been correlated with experimentally derived trends in reactivity. Mechanistically, most reactions involve a formal hydride transfer from an activated C-H bond to the oxygen atom of the oxoammonium cation. Several new potential modes of reactivity have been uncovered and validated experimentally.

Fluoro-substituted ketones from nitriles using acidic and basic reaction conditions

Fluoro-substituted aliphatic nitriles are shown to undergo the Houben-Hoesch reactions with arenes in CF3SO3H to give fluoro-substituted ketones in good yields. The fluorine substituents appear to enhance the reactivities of the nitriles (and the nitrilium ion intermediates) compared to similar aliphatic nitriles. Fluoro-substituted ketones are also shown to be accessible through the reactions of organometallic reagents and fluoro-substituted nitriles.