77257-03-5Relevant articles and documents
Development and Scale-Up of Stereoretentive α-Deuteration of Amines
Michelotti, Alessia,Rodrigues, Fabien,Roche, Maxime
supporting information, p. 1741 - 1744 (2017/11/24)
A stereoretentive deuteration of amino acids and amines has been developed using ruthenium on carbon catalyst, hydrogen gas at atmospheric pressure, and deuterium oxide as a source of deuterium. The process was successfully scaled-up, avoiding the use of expensive and sensitive catalyst and avoiding the use of deuterium gas under pressure. High deuterium incorporation and high yield of labeled compounds were obtained by a simple filtration process.
Enantiospecific C-H Activation Using Ruthenium Nanocatalysts
Taglang, Céline,Martínez-Prieto, Luis Miguel,Del Rosal, Iker,Maron, Laurent,Poteau, Romuald,Philippot, Karine,Chaudret, Bruno,Perato, Serge,Sam Lone, Ana?s,Puente, Céline,Dugave, Christophe,Rousseau, Bernard,Pieters, Grégory
supporting information, p. 10474 - 10477 (2015/09/02)
The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.
PREPARATION OF α-DEUTERATED L-AMINO ACIDS USING E. coli B/It7-A CELLS CONTAINING TRYPTOPHANASE
Faleev, N. G.,Ruvinov, S. B.,Saporovskaya, M. B.,Belikov, V. M.,Zakomyrdina, L. N.,et al.
, p. 7051 - 7054 (2007/10/02)
A convenient method of preparation of α-deuterated L-amino acids via stereospecific isotope exchange in D2O catalyzed by lyophilized E. coli B/It7-A cells abundant in tryptophanase is reported
