77259-96-2

Basic information

• Product Name: 5-broMo-8-Methoxy-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 5-Bromo-3,4-dihydro-8-methoxy-1(2H)-naphthalenone;1(2H)-Naphthalenone, 5-broMo-3,4-dihydro-8-Methoxy-;5-broMo-8-Methoxy-3,4-dihydronaphthalen-1(2H)-one;5-bromo-8-methoxy-3,4-dihydro-2H-naphthalen-1-one
• CAS NO: 77259-96-2
• Molecular Formula: C₁₁H₁₁BrO₂
• Molecular Weight: 255.10784
• Mol File: 77259-96-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.475
• CAS DataBase Reference: 5-broMo-8-Methoxy-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-8-Methoxy-3,4-dihydronaphthalen-1(2H)-one(77259-96-2)
• EPA Substance Registry System: 5-broMo-8-Methoxy-3,4-dihydronaphthalen-1(2H)-one(77259-96-2)

Safety Data

• Hazardous Substances Data: 77259-96-2(Hazardous Substances Data)

Usage

General Description

5-bromo-8-methoxy-3,4-dihydronaphthalen-1(2H)-one is a chemical compound with the molecular formula C11H11BrO2. It is a naphthalen-1(2H)-one derivative, which means it is a compound based on the structure of naphthalene with a ketone functional group. This chemical is characterized by the presence of a bromine atom and a methoxy group attached to the naphthalene ring. It is commonly used in organic synthesis and pharmaceutical research due to its potential applications in the development of various medicinal drugs and other organic compounds. The compound may also be used as an intermediate in the production of other chemical substances.

Upstream product

• 77259-95-1 γ-(2-bromo-5-methoxyphenyl)butyric acid 
• 77260-10-7 C₁₂H₁₄BrN₃O₂ 
• 24743-11-1 4-(m-methoxyphenyl)butanoic acid 
• 75-09-2 dichloromethane 
• 1255944-64-9 3-carboxy-5-bromo-8-methoxy-1-tetralone 
• 766-85-8 3-methoxy-1-iodobenzene 
• 137744-81-1 (E)-4-(m-methoxyphenyl)but-3-enoic acid 
• 57816-04-3 methyl 4-(3-methoxyphenyl)butanoate 

Downstream Products

• 13185-18-7 8-methoxy-1-tetralone 
• 101819-51-6 5-bromo-8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone 
• 77260-09-4 N-[5-Bromo-8-methoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-N'-(2,4-dinitro-phenyl)-hydrazine 
• 77260-14-1 N-(2,4-Dinitro-phenyl)-N'-[8-methoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-hydrazine 
• 77260-11-8 N-[5-Bromo-8-methoxy-1-methyl-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-N'-(2,4-dinitro-phenyl)-hydrazine 
• 77260-18-5 N-(2,4-Dinitro-phenyl)-N'-[5-methoxy-4a-methyl-4,4a,9,10-tetrahydro-3H-phenanthren-(2E)-ylidene]-hydrazine 
• 77260-16-3 N-[8-Bromo-5-methoxy-4a-methyl-4,4a,9,10-tetrahydro-3H-phenanthren-(2E)-ylidene]-N'-(2,4-dinitro-phenyl)-hydrazine 

Relevant articles and documents

An Expeditious Synthesis of 8-Methoxy-1-tetralone

8-Methoxy-1-tetralone was synthesized in a concise and efficient manner involving a sequential palladium-mediated cross-coupling reaction (Heck), catalytic hydrogenation, and intramolecular acylation mediated by Eaton's reagent or Lewis acids. The pivotal step in the synthesis was the use of a bromine substituent at the benzenoid C4 position of the intermediate methyl 4-arylbutyric ester to ensure cyclization ortho to the methoxy moiety and obviate cyclization at the para position to the thermodynamically preferred 6-methoxy-1-tetralone, the sole product obtained in the absence of this blocking group.

TETRAHYDRO-6,7-DIMETHOXY-1H-BENZ[E]ISOINODOLINES USEFUL IN THE TREATMENT OF HYPERTENSION AND AS SEDATIVES

Disclosed herein are tetrahydro-benzo e!isoindolines represented by the formula STR1 wherein R, R 1 and R 2 are independently selected from hydrogen, loweralkyl of 1 to 4 carbon atoms, hydroxy, loweralkoxy of 1 to 3 carbon atoms, allyloxy, benzyloxy, benzoyloxy, thiomethyl, halo, STR2 wherein t is 0 or 1, n is 0 to 5 and R 11 and R 14 are independently selected from hydrogen, halo, hydroxy, loweralkyl of 1 to 4 carbon atoms, loweralkoxy of 1 to 3 carbon atoms or amino; orR and R. sub.1, or R 1 and R 2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R 1 or R 2 must be other than hydrogen and the proviso that two of R, R 1, or R 2 must be other than methoxy in the 7 and 8 positions when the remaining one of R, R 1 or R 2 is hydrogen; andR 3 is hydrogen, loweralkyl of 1 to 4 carbon atoms, halo-substituted loweralkyl of 1 to 4 carbon atoms, amino-substituted loweralkyl of 1 to 4 carbon atoms, amino-substituted arylalkyl, allyl, thioloweralkyl, loweralkanol, or STR3 wherein R 12 and R 13 are independently selected from hydrogen, hydroxy, amino, loweralkoxy of 1 to 3 carbon atoms and s is 1 to 3; or STR4 wherein m is 0, 1 or 2, p is 0 or 1, R 7 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R 8 and R 9 are independently selected from hydrogen, hydroxy, methoxy, loweralkyl of 1 to 4 carbon atoms, or halo, or R 8 and R 9 can be taken together to form a methylenedioxy or ethylenedioxy bridge; or 1,4-benzodioxan of the formula STR5 wherein q is 1, 2 or 3, and R 10 is hydrogen, methoxy, amino, or halo; and the pharmaceutically acceptable salts thereof.